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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Low Free Testosterone and Prostate Cancer Risk: A Collaborative Analysis of 20 Prospective Studies
|
|---|---|
| Published in |
European Urology, August 2018
|
| DOI | 10.1016/j.eururo.2018.07.024 |
| Pubmed ID | |
| Authors |
Eleanor L. Watts, Paul N. Appleby, Aurora Perez-Cornago, H. Bas Bueno-de-Mesquita, June M. Chan, Chu Chen, Barbara A. Cohn, Michael B. Cook, Leon Flicker, Neal D. Freedman, Graham G. Giles, Edward Giovannucci, Randi E. Gislefoss, Graeme J. Hankey, Rudolf Kaaks, Paul Knekt, Laurence N. Kolonel, Tatsuhiko Kubo, Loïc Le Marchand, Robert N. Luben, Tapio Luostarinen, Satu Männistö, E. Jeffrey Metter, Kazuya Mikami, Roger L. Milne, Kotaro Ozasa, Elizabeth A. Platz, J. Ramón Quirós, Harri Rissanen, Norie Sawada, Meir Stampfer, Frank Z. Stanczyk, Pär Stattin, Akiko Tamakoshi, Catherine M. Tangen, Ian M. Thompson, Konstantinos K. Tsilidis, Shoichiro Tsugane, Giske Ursin, Lars Vatten, Noel S. Weiss, Bu B. Yeap, Naomi E. Allen, Timothy J. Key, Ruth C. Travis |
| Abstract |
Experimental and clinical evidence implicates testosterone in the aetiology of prostate cancer. Variation across the normal range of circulating free testosterone concentrations may not lead to changes in prostate biology, unless circulating concentrations are low. This may also apply to prostate cancer risk, but this has not been investigated in an epidemiological setting. To examine whether men with low concentrations of circulating free testosterone have a reduced risk of prostate cancer. Analysis of individual participant data from 20 prospective studies including 6933 prostate cancer cases, diagnosed on average 6.8 yr after blood collection, and 12 088 controls in the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group. Odds ratios (ORs) of incident overall prostate cancer and subtypes by stage and grade, using conditional logistic regression, based on study-specific tenths of calculated free testosterone concentration. Men in the lowest tenth of free testosterone concentration had a lower risk of overall prostate cancer (OR=0.77, 95% confidence interval [CI] 0.69-0.86; p<0.001) compared with men with higher concentrations (2nd-10th tenths of the distribution). Heterogeneity was present by tumour grade (phet=0.01), with a lower risk of low-grade disease (OR=0.76, 95% CI 0.67-0.88) and a nonsignificantly higher risk of high-grade disease (OR=1.56, 95% CI 0.95-2.57). There was no evidence of heterogeneity by tumour stage. The observational design is a limitation. Men with low circulating free testosterone may have a lower risk of overall prostate cancer; this may be due to a direct biological effect, or detection bias. Further research is needed to explore the apparent differential association by tumour grade. In this study, we looked at circulating testosterone levels and risk of developing prostate cancer, finding that men with low testosterone had a lower risk of prostate cancer. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 13% |
| United States | 2 | 13% |
| Switzerland | 1 | 6% |
| Saudi Arabia | 1 | 6% |
| Argentina | 1 | 6% |
| Poland | 1 | 6% |
| United Kingdom | 1 | 6% |
| Unknown | 7 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 69% |
| Science communicators (journalists, bloggers, editors) | 2 | 13% |
| Practitioners (doctors, other healthcare professionals) | 2 | 13% |
| Scientists | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 145 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 145 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 12% |
| Student > Master | 15 | 10% |
| Student > Bachelor | 13 | 9% |
| Student > Ph. D. Student | 11 | 8% |
| Student > Doctoral Student | 7 | 5% |
| Other | 23 | 16% |
| Unknown | 59 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 45 | 31% |
| Biochemistry, Genetics and Molecular Biology | 8 | 6% |
| Nursing and Health Professions | 7 | 5% |
| Agricultural and Biological Sciences | 7 | 5% |
| Immunology and Microbiology | 2 | 1% |
| Other | 16 | 11% |
| Unknown | 60 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2023.
All research outputs
#1,972,221
of 25,385,509 outputs
Outputs from European Urology
#1,278
of 6,218 outputs
Outputs of similar age
#39,793
of 341,886 outputs
Outputs of similar age from European Urology
#33
of 102 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,218 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.1. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,886 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 102 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.