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5-hydroxymethylcytosine but not MTAP methylation status can stratify malignant pleural mesothelioma based on the lineage of origin

Overview of attention for article published in Multidisciplinary Respiratory Medicine, August 2018
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Title
5-hydroxymethylcytosine but not MTAP methylation status can stratify malignant pleural mesothelioma based on the lineage of origin
Published in
Multidisciplinary Respiratory Medicine, August 2018
DOI 10.1186/s40248-018-0137-4
Pubmed ID
Authors

Matteo Bosio, Elena Salvaterra, Francesca Datturi, Patrizia Morbini, Michele Zorzetto, Simona Inghilleri, Stefano Tomaselli, Patrizia Mangiarotti, Federica Meloni, Isa Cerveri, Giulia Maria Stella

Abstract

Malignant pleural mesothelioma (MPM) is an aggressive tumor with poor prognosis, mainly associated with work or environmental exposure to asbestos. MPM's molecular profile is largerly unexplored and effective therapies are still lacking. MPM rarely harbours those somatic genetic lesions that usually characterize solid epithelial-derived tumors. On this basis, our study aims at investigating MPM epigenetic profile. We here assessed through immunohistochemistry, FISH and methylation specific PCR, the expression of 5-hydroxymethylcytosine (5- hmC) - an epigenetic marker and an important regulator of embryonic development and carcinogenesis - and the methylation status of the promoter of the MTAP gene - encoding for an enzyme involved in the rescue process of methionine and adenine - in two relevant series of FF-PE MPM samples derived from MPM thoracoscopic biopsies. Tissue sampling was performed at diagnosis. Within the limitations of the study cohort, the 5-hmC immunophenotype was different among the histological MPM types analysed. In fact, 18% of the epithelial MPMs were negative, 47% weakly positive, and 35% of the cases showed an intense expression of 5-hmC. Sarcomatoid and biphasic MPMs showed intense 5-hmC expression pattern (positive and weakly positive in more than 80% of cases). Among MPM featuring epithelial lineage, none showed methylation of MTAP promoter. Mesothelial sarcomatoid tumors featured a methylation profile characterized by a permanent gene silencing. Epithelial MPM methylation profile was in-between that of sarcomatoid MPM and the one of epithelial-derived tumors. MTAP promoter methylation level cannot be considered a suitable biomarker of epithelial MPM arousal.

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Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 33%
Student > Ph. D. Student 1 17%
Librarian 1 17%
Other 1 17%
Unknown 1 17%
Readers by discipline Count As %
Medicine and Dentistry 2 33%
Social Sciences 2 33%
Biochemistry, Genetics and Molecular Biology 1 17%
Arts and Humanities 1 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2018.
All research outputs
#10,221,195
of 13,401,480 outputs
Outputs from Multidisciplinary Respiratory Medicine
#152
of 228 outputs
Outputs of similar age
#184,977
of 268,301 outputs
Outputs of similar age from Multidisciplinary Respiratory Medicine
#6
of 7 outputs
Altmetric has tracked 13,401,480 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 228 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
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