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Immunomodulatory actions of central ghrelin in diet-induced energy imbalance

Overview of attention for article published in Brain, Behavior & Immunity, January 2012
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Title
Immunomodulatory actions of central ghrelin in diet-induced energy imbalance
Published in
Brain, Behavior & Immunity, January 2012
DOI 10.1016/j.bbi.2011.08.009
Pubmed ID
Authors

Darko Stevanovic, Vesna Starcevic, Urosh Vilimanovich, Dejan Nesic, Ljubica Vucicevic, Maja Misirkic, Kristina Janjetovic, Emina Savic, Dusan Popadic, Emina Sudar, Dragan Micic, Mirjana Sumarac-Dumanovic, Vladimir Trajkovic

Abstract

We investigated the effects of centrally administered orexigenic hormone ghrelin on energy imbalance-induced inflammation. Rats were subjected for four weeks to three different dietary regimes: normal (standard food), high-fat (standard food with 30% lard) or food-restricted (70%, 50%, 40% and 40% of the expected food intake in 1st, 2nd, 3rd and 4th week, respectively). Compared to normal-weight controls, starved, but not obese rats had significantly higher levels of proinflammatory cytokines (TNF, IL-1β, IFN-γ) in the blood. When compared to normally fed animals, the hearts of starved and obese animals expressed higher levels of mRNAs encoding proinflammatory mediators (TNF, IL-1β, IL-6, IFN-γ, IL-17, IL-12, iNOS), while mRNA levels of the anti-inflammatory TGF-β remained unchanged. Intracerebroventricular (ICV) injection of ghrelin (1 μg/day) for five consecutive days significantly reduced TNF, IL-1β and IFN-γ levels in the blood of starved rats, as well as TNF, IL-17 and IL-12p40 mRNA expression in the hearts of obese rats. Conversely, ICV ghrelin increased the levels of IFN-γ, IL-17, IL-12p35 and IL-12p40 mRNA in the heart tissue of food-restricted animals. This was associated with an increase of immunosuppressive ACTH/corticosterone production in starved animals and a decrease of the immunostimulatory adipokine leptin both in food-restricted and high-fat groups. Ghrelin activated the energy sensor AMP-activated protein kinase (AMPK) in the hypothalamus and inhibited extracellular signal-regulated kinase (ERK) in the hearts of obese, but not starved rats. Therefore, central ghrelin may play a complex role in energy imbalance-induced inflammation by modulating HPA axis, leptin and AMPK/ERK signaling pathways.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Serbia 1 3%
Argentina 1 3%
Brazil 1 3%
Unknown 36 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 28%
Student > Ph. D. Student 5 13%
Student > Master 5 13%
Professor 4 10%
Student > Doctoral Student 3 8%
Other 9 23%
Unknown 3 8%
Readers by discipline Count As %
Medicine and Dentistry 11 28%
Agricultural and Biological Sciences 10 25%
Immunology and Microbiology 4 10%
Biochemistry, Genetics and Molecular Biology 3 8%
Neuroscience 3 8%
Other 7 18%
Unknown 2 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2011.
All research outputs
#9,760,912
of 12,211,903 outputs
Outputs from Brain, Behavior & Immunity
#1,365
of 1,779 outputs
Outputs of similar age
#169,750
of 239,017 outputs
Outputs of similar age from Brain, Behavior & Immunity
#27
of 34 outputs
Altmetric has tracked 12,211,903 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,779 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.5. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,017 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.