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The effect of “Jelly” CdTe QD uptake on RAW264.7 monocytes: immune responses and cell fate study

Overview of attention for article published in Toxicology Research, October 2015
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Title
The effect of “Jelly” CdTe QD uptake on RAW264.7 monocytes: immune responses and cell fate study
Published in
Toxicology Research, October 2015
DOI 10.1039/c5tx00153f
Pubmed ID
Authors

Olga Gladkovskaya, Alex Loudon, Mikhail Nosov, Y Gunko, Gerard O'Connor, Yury Rochev, O. Gladkovskaya, A. Loudon, M. Nosov, Y. K. Gun'ko, G. M. O'Connor, Y. Rochev

Abstract

Encapsulation of Quantum Dots (QDs) has become an essential factor which regulates particles cytotoxicity, as well as physical and chemical stability. Negatively charged cellular membranes have a great affinity to nanoparticles with surface molecules carrying positive charge, hence creating perfect conditions for fast and aggressive intracellular penetration. The preference for non-charged outer shells is topical in QD design and various applications. In the current paper we develop gelatination as a prominent coating approach to create neutrally passivated QDs with improved biocompatibility. We have revealed the trends in particle's uptake, accumulation, intracellular localisation and retaining time as well as RAW264.7 monocyte cell fate and immune responses. Also the difference in particle endocytosis kinetics and dynamics has been shown to depend on the QD core size. The intracellular QD content along with cell responses at the population level was quantified by flow cytometry.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 2 50%
Student > Ph. D. Student 1 25%
Student > Master 1 25%
Readers by discipline Count As %
Unspecified 3 75%
Materials Science 1 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2015.
All research outputs
#5,540,711
of 6,496,325 outputs
Outputs from Toxicology Research
#221
of 346 outputs
Outputs of similar age
#165,162
of 207,026 outputs
Outputs of similar age from Toxicology Research
#12
of 43 outputs
Altmetric has tracked 6,496,325 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 346 research outputs from this source. They receive a mean Attention Score of 1.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.