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Testosterone plays a permissive role in angiotensin II-induced hypertension and cardiac hypertrophy in male rats†

Overview of attention for article published in Biology of Reproduction, August 2018
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  • Above-average Attention Score compared to outputs of the same age (56th percentile)
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Mentioned by

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6 tweeters

Citations

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3 Dimensions

Readers on

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7 Mendeley
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Title
Testosterone plays a permissive role in angiotensin II-induced hypertension and cardiac hypertrophy in male rats†
Published in
Biology of Reproduction, August 2018
DOI 10.1093/biolre/ioy179
Pubmed ID
Authors

Jay S Mishra, Amar S More, Kathirvel Gopalakrishnan, Sathish Kumar

Abstract

Sex hormone-dependent vascular reactivity is an underlying factor contributing to sex differences in blood pressure. Inappropriate activation of the renin-angiotensin system (RAS) is involved in vascular dysfunction and hypertension. This study evaluated the role of androgens (testosterone) in angiotensin II (Ang II) -induced increase in blood pressure, vascular reactivity and cardiac hypertrophy. Eight weeks-old male Wistar rats underwent sham operation, castration, or castration with testosterone replacement. After 12 weeks of chronic changes in androgen status, Ang II (120 ng/kg per minute) or saline was infused for 28 days via subcutaneous miniosmotic pump, and changes in blood pressure was measured. Vascular reactivity and Ang II receptor levels were examined in mesenteric arteries. Heart weight, cardiac ANP mRNA levels and fibrosis were also assessed. Ang II infusion increased arterial pressure in intact males. The Ang II-induced increase in hypertensive response was prevented in castrated males. Testosterone replacement in castrated males restored Ang II-induced hypertensive responses. Castration reduced vascular AT1R/AT2R ratio, an effect that was reversed by testosterone replacement. Ang II-induced hypertension was associated with increased contractile response of mesenteric arteries to Ang II and phenylephrine in intact and testosterone-replaced castrated males; these increases were prevented in castrated males. Ang II infusion induced increased left ventricle-to-body weight ratio and ANP mRNA expression, indicators of left ventricular hypertrophy, and fibrosis in intact and testosterone-replaced castrated males, and castration prevented the increase in these parameters caused by Ang II. This study demonstrate that testosterone plays a permissive role in development and maintenance of Ang II-induced vascular dysfunction, hypertension and cardiac hypertrophy.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 29%
Student > Ph. D. Student 1 14%
Other 1 14%
Student > Master 1 14%
Researcher 1 14%
Other 0 0%
Unknown 1 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 57%
Nursing and Health Professions 1 14%
Medicine and Dentistry 1 14%
Unknown 1 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2020.
All research outputs
#7,984,468
of 15,132,971 outputs
Outputs from Biology of Reproduction
#2,353
of 4,199 outputs
Outputs of similar age
#118,509
of 276,654 outputs
Outputs of similar age from Biology of Reproduction
#32
of 60 outputs
Altmetric has tracked 15,132,971 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,199 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,654 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.