Title |
Dissemination of clonal complex 2 Acinetobacter baumannii strains co-producing carbapenemases and 16S rRNA methylase ArmA in Vietnam
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Published in |
BMC Infectious Diseases, October 2015
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DOI | 10.1186/s12879-015-1171-x |
Pubmed ID | |
Authors |
Tatsuya Tada, Tohru Miyoshi-Akiyama, Kayo Shimada, Tran Thi Thanh Nga, Le Thi Anh Thu, Nguyen Truong Son, Norio Ohmagari, Teruo Kirikae |
Abstract |
Acinetobacter baumannii strains co-producing carbapenemase and 16S rRNA methylase are highly resistant to carbapenems and aminoglycosides. Ninety-three isolates of multidrug-resistant A. baumannii were obtained from an intensive care unit in a hospital in Vietnam. Antimicrobial susceptibility tests and whole genome sequencing were performed. Multilocus sequence typing and the presence of drug resistant genes were determined and a maximum-likelihood phylogenetic tree was constructed by SNP alignment of whole genome sequencing data. The majority of isolates belonged to clonal complex 2 (ST2, ST570 and ST571), and carried carbapenemase encoding genes bla OXA-23 and bla OXA-66. Two isolates encoded carbapenemase genes bla NDM-1 and bla OXA-58 and the 16S rRNA methylase encoding gene armA and did not belong to clonal complex 2 (ST16). A. baumannii isolates producing 16S rRNA methylase ArmA and belonging to clonal complex 2 are widespread, and isolates co-producing NDM-1 and ArmA are emerging, in medical settings in Vietnam. |
X Demographics
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United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
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Members of the public | 3 | 100% |
Mendeley readers
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Malaysia | 1 | 2% |
Unknown | 51 | 98% |
Demographic breakdown
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Researcher | 9 | 17% |
Student > Ph. D. Student | 8 | 15% |
Student > Master | 7 | 13% |
Student > Doctoral Student | 4 | 8% |
Student > Postgraduate | 4 | 8% |
Other | 10 | 19% |
Unknown | 10 | 19% |
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Biochemistry, Genetics and Molecular Biology | 9 | 17% |
Agricultural and Biological Sciences | 8 | 15% |
Immunology and Microbiology | 5 | 10% |
Medicine and Dentistry | 4 | 8% |
Unspecified | 3 | 6% |
Other | 9 | 17% |
Unknown | 14 | 27% |