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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cardiovascular and inflammatory mechanisms in healthy humans exposed to air pollution in the vicinity of a steel mill
|
|---|---|
| Published in |
Particle and Fibre Toxicology, August 2018
|
| DOI | 10.1186/s12989-018-0270-4 |
| Pubmed ID | |
| Authors |
Premkumari Kumarathasan, Renaud Vincent, Erica Blais, Agnieszka Bielecki, Josée Guénette, Alain Filiatreault, Orly Brion, Sabit Cakmak, Errol M. Thomson, Robin Shutt, Lisa Marie Kauri, Mamun Mahmud, Ling Liu, Robert Dales |
| Abstract |
There is a paucity of mechanistic information that is central to the understanding of the adverse health effects of source emission exposures. To identify source emission-related effects, blood and saliva samples from healthy volunteers who spent five days near a steel plant (Bayview site, with and without a mask that filtered many criteria pollutants) and at a well-removed College site were tested for oxidative stress, inflammation and endothelial dysfunction markers. Biomarker analyses were done using multiplexed protein-array, HPLC-Fluorescence, EIA and ELISA methods. Mixed effects models were used to test for associations between exposure, biological markers and physiological outcomes. Heat map with hierarchical clustering and Ingenuity Pathway Analysis (IPA) were used for mechanistic analyses. Mean CO, SO2 and ultrafine particles (UFP) levels on the day of biological sampling were higher at the Bayview site compared to College site. Bayview site exposures "without" mask were associated with increased (p < 0.05) pro-inflammatory cytokines (e.g IL-4, IL-6) and endothelins (ETs) compared to College site. Plasma IL-1β, IL-2 were increased (p < 0.05) after Bayview site "without" compared to "with" mask exposures. Interquartile range (IQR) increases in CO, UFP and SO2 were associated with increased (p < 0.05) plasma pro-inflammatory cytokines (e.g. IL-6, IL-8) and ET-1(1-21) levels. Plasma/saliva BET-1 levels were positively associated (p < 0.05) with increased systolic BP. C-reactive protein (CRP) was positively associated (p < 0.05) with increased heart rate. Protein network analyses exhibited activation of distinct inflammatory mechanisms after "with" and "without" mask exposures at the Bayview site relative to College site exposures. These findings suggest that air pollutants in the proximity of steel mill site can influence inflammatory and vascular mechanisms. Use of mask and multiple biomarker data can be valuable in gaining insight into source emission-related health impacts. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 92 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 13% |
| Student > Bachelor | 11 | 12% |
| Student > Master | 9 | 10% |
| Researcher | 8 | 9% |
| Student > Postgraduate | 5 | 5% |
| Other | 15 | 16% |
| Unknown | 32 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 20% |
| Environmental Science | 8 | 9% |
| Nursing and Health Professions | 6 | 7% |
| Sports and Recreations | 6 | 7% |
| Agricultural and Biological Sciences | 4 | 4% |
| Other | 12 | 13% |
| Unknown | 38 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2018.
All research outputs
#20,529,980
of 23,099,576 outputs
Outputs from Particle and Fibre Toxicology
#466
of 564 outputs
Outputs of similar age
#289,023
of 331,118 outputs
Outputs of similar age from Particle and Fibre Toxicology
#7
of 10 outputs
Altmetric has tracked 23,099,576 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 564 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,118 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.