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Sex differences and the role of IL-10 in ischemic stroke recovery

Overview of attention for article published in Biology of Sex Differences, October 2015
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Title
Sex differences and the role of IL-10 in ischemic stroke recovery
Published in
Biology of Sex Differences, October 2015
DOI 10.1186/s13293-015-0035-9
Pubmed ID
Authors

Sarah E Conway, Meaghan Roy-O’Reilly, Brett Friedler, Ilene Staff, Gilbert Fortunato, Louise D McCullough

Abstract

Females experience poorer recovery after ischemic stroke compared to males, even after controlling for age and stroke severity. IL-10 is an anti-inflammatory cytokine produced by T regulatory cells and Th2 CD4(+) helper T cells. In ischemic stroke, an excessive IL-10 response contributes to post-stroke immunosuppression, which worsens outcomes. However, it is unknown if sex differences exist in IL-10 levels after ischemic stroke. In this study, we found that higher levels of IL-10 were associated with poor acute and long-term outcomes after ischemic stroke in female patients but not in males. After controlling for confounders, IL-10 was not an independent predictor of functional outcomes. This suggests that higher serum IL-10 levels may reflect factors that interact with sex such as age and stroke severity.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 23%
Student > Ph. D. Student 6 17%
Researcher 4 11%
Student > Master 3 9%
Student > Postgraduate 2 6%
Other 4 11%
Unknown 8 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 17%
Neuroscience 6 17%
Medicine and Dentistry 6 17%
Immunology and Microbiology 3 9%
Biochemistry, Genetics and Molecular Biology 3 9%
Other 3 9%
Unknown 8 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2015.
All research outputs
#18,429,163
of 22,830,751 outputs
Outputs from Biology of Sex Differences
#420
of 472 outputs
Outputs of similar age
#200,678
of 279,097 outputs
Outputs of similar age from Biology of Sex Differences
#10
of 11 outputs
Altmetric has tracked 22,830,751 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 472 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.9. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,097 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.