Title |
Sex differences and the role of IL-10 in ischemic stroke recovery
|
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Published in |
Biology of Sex Differences, October 2015
|
DOI | 10.1186/s13293-015-0035-9 |
Pubmed ID | |
Authors |
Sarah E Conway, Meaghan Roy-O’Reilly, Brett Friedler, Ilene Staff, Gilbert Fortunato, Louise D McCullough |
Abstract |
Females experience poorer recovery after ischemic stroke compared to males, even after controlling for age and stroke severity. IL-10 is an anti-inflammatory cytokine produced by T regulatory cells and Th2 CD4(+) helper T cells. In ischemic stroke, an excessive IL-10 response contributes to post-stroke immunosuppression, which worsens outcomes. However, it is unknown if sex differences exist in IL-10 levels after ischemic stroke. In this study, we found that higher levels of IL-10 were associated with poor acute and long-term outcomes after ischemic stroke in female patients but not in males. After controlling for confounders, IL-10 was not an independent predictor of functional outcomes. This suggests that higher serum IL-10 levels may reflect factors that interact with sex such as age and stroke severity. |
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