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Twitter Demographics
Mendeley readers
Attention Score in Context
| Title |
DNA methylation 101: what is important to know about DNA methylation and its role in SLE risk and disease heterogeneity
|
|---|---|
| Published in |
Lupus Science & Medicine, July 2018
|
| DOI | 10.1136/lupus-2018-000285 |
| Pubmed ID | |
| Authors |
Cristina M Lanata, Sharon A Chung, Lindsey A Criswell |
| Abstract |
SLE is a complex autoimmune disease that results from the interplay of genetics, epigenetics and environmental exposures. DNA methylation is an epigenetic mechanism that regulates gene expression and tissue differentiation. Among all the epigenetic modifications, DNA methylation perturbations have been the most widely studied in SLE. It mediates processes relevant to SLE, including lymphocyte development, X-chromosome inactivation and the suppression of endogenous retroviruses. The establishment of most DNA methylation marks occurs in utero; however, a small percentage of epigenetic marks are dynamic and can change throughout a person's lifetime and in relation to exposures. In this review, we discuss the current understanding of the biology of DNA methylation and its regulators, the measurement and interpretation of methylation marks, the effects of genetics on DNA methylation and the role of environmental exposures with relevance to SLE. We also summarise research findings associated with SLE disease risk and heterogeneity. The robust finding of hypomethylation of interferon-responsive genes in patients with SLE and new associations beyond interferon-responsive genes such as cell-specific methylation abnormalities are described. We also discuss methylation changes associated with lupus nephritis, autoantibody status and disease activity. Lastly, we explore future research directions, emphasising the need for longitudinal studies, cell tissue and context-specific profiling, as well as integrative approaches. With new technologies, DNA methylation perturbations could be targeted and edited, offering novel therapeutic approaches. |
Twitter Demographics
The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 25% |
| Venezuela, Bolivarian Republic of | 1 | 25% |
| France | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 101 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 18% |
| Researcher | 13 | 13% |
| Student > Bachelor | 12 | 12% |
| Other | 8 | 8% |
| Student > Master | 5 | 5% |
| Other | 11 | 11% |
| Unknown | 34 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 23% |
| Biochemistry, Genetics and Molecular Biology | 13 | 13% |
| Agricultural and Biological Sciences | 10 | 10% |
| Immunology and Microbiology | 7 | 7% |
| Engineering | 3 | 3% |
| Other | 7 | 7% |
| Unknown | 38 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 80. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2023.
All research outputs
#503,521
of 24,341,979 outputs
Outputs from Lupus Science & Medicine
#15
of 439 outputs
Outputs of similar age
#11,319
of 334,267 outputs
Outputs of similar age from Lupus Science & Medicine
#1
of 10 outputs
Altmetric has tracked 24,341,979 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 439 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.2. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,267 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them