Title |
Immunological hallmarks of stromal cells in the tumour microenvironment
|
---|---|
Published in |
Nature Reviews Immunology, October 2015
|
DOI | 10.1038/nri3902 |
Pubmed ID | |
Authors |
Shannon J. Turley, Viviana Cremasco, Jillian L. Astarita |
Abstract |
A dynamic and mutualistic interaction between tumour cells and the surrounding stroma promotes the initiation, progression, metastasis and chemoresistance of solid tumours. Far less understood is the relationship between the stroma and tumour-infiltrating leukocytes; however, emerging evidence suggests that the stromal compartment can shape antitumour immunity and responsiveness to immunotherapy. Thus, there is growing interest in elucidating the immunomodulatory roles of the stroma that evolve within the tumour microenvironment. In this Review, we discuss the evidence that stromal determinants interact with leukocytes and influence antitumour immunity, with emphasis on the immunological attributes of stromal cells that may foster their protumorigenic function. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 50% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | <1% |
France | 2 | <1% |
United Kingdom | 2 | <1% |
Netherlands | 1 | <1% |
Sweden | 1 | <1% |
Ireland | 1 | <1% |
Korea, Republic of | 1 | <1% |
Denmark | 1 | <1% |
Saudi Arabia | 1 | <1% |
Other | 2 | <1% |
Unknown | 905 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 243 | 26% |
Researcher | 169 | 18% |
Student > Master | 98 | 11% |
Student > Bachelor | 83 | 9% |
Student > Doctoral Student | 57 | 6% |
Other | 120 | 13% |
Unknown | 150 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 209 | 23% |
Agricultural and Biological Sciences | 167 | 18% |
Medicine and Dentistry | 145 | 16% |
Immunology and Microbiology | 107 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 25 | 3% |
Other | 82 | 9% |
Unknown | 185 | 20% |