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LncRNA DLEU1 contributes to colorectal cancer progression via activation of KPNA3

Overview of attention for article published in Molecular Cancer, August 2018
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Title
LncRNA DLEU1 contributes to colorectal cancer progression via activation of KPNA3
Published in
Molecular Cancer, August 2018
DOI 10.1186/s12943-018-0873-2
Pubmed ID
Authors

Tianyou Liu, Zhiyang Han, Huanyu Li, Yuekun Zhu, Ziquan Sun, Anlong Zhu

Abstract

Accumulating evidences show that long noncoding RNAs (lncRNA) play essential roles in the development and progression of various malignancies. However, their functions remains poorly understood and many lncRNAs have not been defined in colorectal cancer (CRC). In this study, we investigated the role of DLEU1 in CRC. Quantitative real-time PCR was used to detect the expression of DLEU1 and survival analysis was adopted to explore the association between DLEU1 expression and the prognosis of CRC patients. CRC cells were stably transfected with lentivirus approach and cell proliferation, migration, invasion and cell apoptosis, as well as tumorigenesis in nude mice were performed to assess the effects of DLEU1 in BCa. Biotin-coupled probe pull down assay, RNA immunoprecipitation and Fluorescence in situ hybridization assays were conducted to confirm the relationship between DLEU1 and SMARCA1. Here we revealed that DLEU1 was crucial for activation of KPNA3 by recruiting SMARCA1, an essential subunit of the NURF chromatin remodeling complex, in CRC. DLEU1 was indispensible for the deposition of SMARCA1 at the promoter of KPNA3 gene. Increased expression of DLEU1 and KPNA3 was observed in human CRC tissues. And higher expression of DLEU1 or KPNA3 in patients indicates lower survival rate and poorer prognosis. DLEU1 knockdown remarkably inhibited CRC cell proliferation, migration and invasion in vitro and in vivo while overexpressing KPNA3 in the meantime reversed it. Our results identify DLEU1 as a key regulator by a novel DLEU1/SMARCA1/KPNA3 axis in CRC development and progression, which may provide a potential biomarker and therapeutic target for the management of CRC.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 27%
Student > Doctoral Student 3 14%
Researcher 2 9%
Student > Ph. D. Student 1 5%
Unspecified 1 5%
Other 2 9%
Unknown 7 32%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 27%
Medicine and Dentistry 3 14%
Agricultural and Biological Sciences 1 5%
Unspecified 1 5%
Immunology and Microbiology 1 5%
Other 1 5%
Unknown 9 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2019.
All research outputs
#22,767,715
of 25,385,509 outputs
Outputs from Molecular Cancer
#1,680
of 1,920 outputs
Outputs of similar age
#298,958
of 341,707 outputs
Outputs of similar age from Molecular Cancer
#28
of 34 outputs
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