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Increased abundance of translation machinery in stem cell–derived neural progenitor cells from four schizophrenia patients

Overview of attention for article published in Translational Psychiatry, October 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
1 news outlet
blogs
5 blogs
twitter
12 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
39 Dimensions

Readers on

mendeley
73 Mendeley
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Title
Increased abundance of translation machinery in stem cell–derived neural progenitor cells from four schizophrenia patients
Published in
Translational Psychiatry, October 2015
DOI 10.1038/tp.2015.118
Pubmed ID
Authors

A Topol, J A English, E Flaherty, P Rajarajan, B J Hartley, S Gupta, F Desland, S Zhu, T Goff, L Friedman, J Rapoport, D Felsenfeld, G Cagney, A Mackay-Sim, J N Savas, B Aronow, G Fang, B Zhang, D Cotter, K J Brennand

Abstract

The genetic and epigenetic factors contributing to risk for schizophrenia (SZ) remain unresolved. Here we demonstrate, for the first time, perturbed global protein translation in human-induced pluripotent stem cell (hiPSC)-derived forebrain neural progenitor cells (NPCs) from four SZ patients relative to six unaffected controls. We report increased total protein levels and protein synthesis, together with two independent sets of quantitative mass spectrometry evidence indicating markedly increased levels of ribosomal and translation initiation and elongation factor proteins, in SZ hiPSC NPCs. We posit that perturbed levels of global protein synthesis in SZ hiPSC NPCs represent a novel post-transcriptional mechanism that might contribute to disease progression.

Twitter Demographics

The data shown below were collected from the profiles of 12 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 1%
Unknown 72 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 21%
Student > Ph. D. Student 13 18%
Student > Master 9 12%
Student > Bachelor 8 11%
Student > Postgraduate 5 7%
Other 13 18%
Unknown 10 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 33%
Neuroscience 15 21%
Biochemistry, Genetics and Molecular Biology 10 14%
Medicine and Dentistry 5 7%
Engineering 3 4%
Other 4 5%
Unknown 12 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 52. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2016.
All research outputs
#466,527
of 16,530,799 outputs
Outputs from Translational Psychiatry
#210
of 2,157 outputs
Outputs of similar age
#11,294
of 287,563 outputs
Outputs of similar age from Translational Psychiatry
#5
of 50 outputs
Altmetric has tracked 16,530,799 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,157 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.7. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,563 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.