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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Increased abundance of translation machinery in stem cell–derived neural progenitor cells from four schizophrenia patients
|
|---|---|
| Published in |
Translational Psychiatry, October 2015
|
| DOI | 10.1038/tp.2015.118 |
| Pubmed ID | |
| Authors |
A Topol, J A English, E Flaherty, P Rajarajan, B J Hartley, S Gupta, F Desland, S Zhu, T Goff, L Friedman, J Rapoport, D Felsenfeld, G Cagney, A Mackay-Sim, J N Savas, B Aronow, G Fang, B Zhang, D Cotter, K J Brennand |
| Abstract |
The genetic and epigenetic factors contributing to risk for schizophrenia (SZ) remain unresolved. Here we demonstrate, for the first time, perturbed global protein translation in human-induced pluripotent stem cell (hiPSC)-derived forebrain neural progenitor cells (NPCs) from four SZ patients relative to six unaffected controls. We report increased total protein levels and protein synthesis, together with two independent sets of quantitative mass spectrometry evidence indicating markedly increased levels of ribosomal and translation initiation and elongation factor proteins, in SZ hiPSC NPCs. We posit that perturbed levels of global protein synthesis in SZ hiPSC NPCs represent a novel post-transcriptional mechanism that might contribute to disease progression. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 8% |
| United States | 1 | 8% |
| Mexico | 1 | 8% |
| United Kingdom | 1 | 8% |
| Unknown | 8 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 92% |
| Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 1% |
| Unknown | 89 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 19% |
| Student > Ph. D. Student | 16 | 18% |
| Student > Bachelor | 10 | 11% |
| Student > Master | 10 | 11% |
| Student > Postgraduate | 5 | 6% |
| Other | 14 | 16% |
| Unknown | 18 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 25 | 28% |
| Neuroscience | 19 | 21% |
| Biochemistry, Genetics and Molecular Biology | 11 | 12% |
| Medicine and Dentistry | 8 | 9% |
| Engineering | 3 | 3% |
| Other | 6 | 7% |
| Unknown | 18 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 50. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2016.
All research outputs
#838,208
of 25,489,496 outputs
Outputs from Translational Psychiatry
#365
of 3,693 outputs
Outputs of similar age
#12,544
of 294,683 outputs
Outputs of similar age from Translational Psychiatry
#7
of 56 outputs
Altmetric has tracked 25,489,496 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,693 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.3. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 294,683 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.