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X Demographics
Mendeley readers
Attention Score in Context
| Title |
An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses
|
|---|---|
| Published in |
Molecular Cell, August 2018
|
| DOI | 10.1016/j.molcel.2018.07.010 |
| Pubmed ID | |
| Authors |
Bennett H. Penn, Zoe Netter, Jeffrey R. Johnson, John Von Dollen, Gwendolyn M. Jang, Tasha Johnson, Yamini M. Ohol, Cyrus Maher, Samantha L. Bell, Kristina Geiger, Guillaume Golovkine, Xiaotang Du, Alex Choi, Trevor Parry, Bhopal C. Mohapatra, Matthew D. Storck, Hamid Band, Chen Chen, Stefanie Jäger, Michael Shales, Dan A. Portnoy, Ryan Hernandez, Laurent Coscoy, Jeffery S. Cox, Nevan J. Krogan |
| Abstract |
Although macrophages are armed with potent antibacterial functions, Mycobacterium tuberculosis (Mtb) replicates inside these innate immune cells. Determinants of macrophage intrinsic bacterial control, and the Mtb strategies to overcome them, are poorly understood. To further study these processes, we used an affinity tag purification mass spectrometry (AP-MS) approach to identify 187 Mtb-human protein-protein interactions (PPIs) involving 34 secreted Mtb proteins. This interaction map revealed two factors involved in Mtb pathogenesis-the secreted Mtb protein, LpqN, and its binding partner, the human ubiquitin ligase CBL. We discovered that an lpqN Mtb mutant is attenuated in macrophages, but growth is restored when CBL is removed. Conversely, Cbl-/- macrophages are resistant to viral infection, indicating that CBL regulates cell-intrinsic polarization between antibacterial and antiviral immunity. Collectively, these findings illustrate the utility of this Mtb-human PPI map for developing a deeper understanding of the intricate interactions between Mtb and its host. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 25% |
| South Africa | 2 | 10% |
| United Kingdom | 2 | 10% |
| Cameroon | 1 | 5% |
| Japan | 1 | 5% |
| Italy | 1 | 5% |
| France | 1 | 5% |
| Denmark | 1 | 5% |
| Unknown | 6 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 60% |
| Scientists | 7 | 35% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 164 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 164 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 21% |
| Researcher | 26 | 16% |
| Student > Doctoral Student | 18 | 11% |
| Student > Bachelor | 16 | 10% |
| Student > Master | 14 | 9% |
| Other | 21 | 13% |
| Unknown | 34 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 44 | 27% |
| Immunology and Microbiology | 33 | 20% |
| Agricultural and Biological Sciences | 21 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Chemistry | 6 | 4% |
| Other | 10 | 6% |
| Unknown | 44 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 424. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2022.
All research outputs
#67,921
of 25,385,509 outputs
Outputs from Molecular Cell
#17
of 7,617 outputs
Outputs of similar age
#1,337
of 341,886 outputs
Outputs of similar age from Molecular Cell
#2
of 107 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,617 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,886 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 107 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.