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An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses

Overview of attention for article published in Molecular Cell, August 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#11 of 6,284)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
52 news outlets
blogs
2 blogs
twitter
25 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
47 Dimensions

Readers on

mendeley
115 Mendeley
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Title
An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses
Published in
Molecular Cell, August 2018
DOI 10.1016/j.molcel.2018.07.010
Pubmed ID
Authors

Bennett H. Penn, Zoe Netter, Jeffrey R. Johnson, John Von Dollen, Gwendolyn M. Jang, Tasha Johnson, Yamini M. Ohol, Cyrus Maher, Samantha L. Bell, Kristina Geiger, Guillaume Golovkine, Xiaotang Du, Alex Choi, Trevor Parry, Bhopal C. Mohapatra, Matthew D. Storck, Hamid Band, Chen, Stefanie Jäger, Michael Shales, Dan A. Portnoy, Ryan Hernandez, Laurent Coscoy, Jeffery S. Cox, Nevan J. Krogan

Abstract

Although macrophages are armed with potent antibacterial functions, Mycobacterium tuberculosis (Mtb) replicates inside these innate immune cells. Determinants of macrophage intrinsic bacterial control, and the Mtb strategies to overcome them, are poorly understood. To further study these processes, we used an affinity tag purification mass spectrometry (AP-MS) approach to identify 187 Mtb-human protein-protein interactions (PPIs) involving 34 secreted Mtb proteins. This interaction map revealed two factors involved in Mtb pathogenesis-the secreted Mtb protein, LpqN, and its binding partner, the human ubiquitin ligase CBL. We discovered that an lpqN Mtb mutant is attenuated in macrophages, but growth is restored when CBL is removed. Conversely, Cbl-/- macrophages are resistant to viral infection, indicating that CBL regulates cell-intrinsic polarization between antibacterial and antiviral immunity. Collectively, these findings illustrate the utility of this Mtb-human PPI map for developing a deeper understanding of the intricate interactions between Mtb and its host.

Twitter Demographics

The data shown below were collected from the profiles of 25 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 115 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 26%
Researcher 20 17%
Student > Doctoral Student 16 14%
Student > Bachelor 11 10%
Student > Master 8 7%
Other 17 15%
Unknown 13 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 29 25%
Immunology and Microbiology 25 22%
Agricultural and Biological Sciences 20 17%
Chemistry 5 4%
Medicine and Dentistry 4 3%
Other 10 9%
Unknown 22 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 421. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2021.
All research outputs
#36,875
of 17,499,602 outputs
Outputs from Molecular Cell
#11
of 6,284 outputs
Outputs of similar age
#934
of 236,129 outputs
Outputs of similar age from Molecular Cell
#2
of 64 outputs
Altmetric has tracked 17,499,602 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,284 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 236,129 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.