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Possible changes in the transmissibility of trachoma following MDA and transmission reduction: implications for the GET2020 goals

Overview of attention for article published in Parasites & Vectors, October 2015
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Title
Possible changes in the transmissibility of trachoma following MDA and transmission reduction: implications for the GET2020 goals
Published in
Parasites & Vectors, October 2015
DOI 10.1186/s13071-015-1133-6
Pubmed ID
Authors

Manoj Gambhir, Amy Pinsent

Abstract

The role of mass drug administration (MDA) and the implementation of transmission reduction measures are essential to successfully control and eliminate a wide range of NTDs, including the ocular disease trachoma. Immunity to trachoma infection acts by reducing the duration of an individual's infectious period and by reducing their infectivity with each successive infection. In this study, we use a model of trachoma infection, which includes population immunity, to explore the impact of treatment and transmission reduction measures on trachoma prevalence. Specifically, we investigate the possibility of increasing transmissibility of trachoma arising as MDA and transmission reduction measures are scaled up in endemic settings. We demonstrate this increase in transmissibility by calculating the effective reproduction number during several simulated control programmes and show that it is related to a decrease in the level of immunity in the population. This effect should be studied in the field by measuring the rate of return of infection and disease in at least two separate age groups. If the decline of population immunity is operating, it should be accounted for when planning for the GET2020 goal of eliminating blinding trachoma by 2020.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 25%
Student > Master 5 18%
Student > Ph. D. Student 4 14%
Student > Bachelor 2 7%
Student > Postgraduate 2 7%
Other 3 11%
Unknown 5 18%
Readers by discipline Count As %
Medicine and Dentistry 8 29%
Agricultural and Biological Sciences 4 14%
Biochemistry, Genetics and Molecular Biology 2 7%
Social Sciences 2 7%
Mathematics 1 4%
Other 5 18%
Unknown 6 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 October 2015.
All research outputs
#18,429,163
of 22,830,751 outputs
Outputs from Parasites & Vectors
#4,228
of 5,465 outputs
Outputs of similar age
#203,804
of 283,279 outputs
Outputs of similar age from Parasites & Vectors
#111
of 160 outputs
Altmetric has tracked 22,830,751 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,465 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,279 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 160 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.