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Inhibitory effect of curcumin on testosterone induced benign prostatic hyperplasia rat model

Overview of attention for article published in BMC Complementary and Alternative Medicine, October 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

twitter
6 tweeters
wikipedia
1 Wikipedia page
reddit
1 Redditor
video
2 video uploaders

Citations

dimensions_citation
16 Dimensions

Readers on

mendeley
20 Mendeley
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Title
Inhibitory effect of curcumin on testosterone induced benign prostatic hyperplasia rat model
Published in
BMC Complementary and Alternative Medicine, October 2015
DOI 10.1186/s12906-015-0825-y
Pubmed ID
Authors

Su Kang Kim, Hosik Seok, Hae Jeong Park, Hye Sook Jeon, Sang Wook Kang, Byung-Cheol Lee, Jooil Yi, Sang Yeol Song, Sang Hyub Lee, Young Ock Kim, Joo-Ho Chung

Abstract

Benign prostatic hyperplasia (BPH) is one of the common male diseases, which is provoked by dihydrotestosterone (DHT) and androgen signals. Several studies showed that curcumin has various effects of prevention and treatment to diseases. We investigated whether curcumin may repress the development of BPH in male Wistar rats. Seven weeks male Wistar rats were and divided into 4 groups (normal group, BPH group, finasteride group, curcumin group; n = 8 for each group). In order to induce BPH in rats, rats were castrated and testosterone was injected subcutaneously everyday (s.c., 20 mg/kg). Rats in the curcumin group were treated 50 mg/kg, administered orally for 4 weeks. After 4 weeks, all rats were sacrificed and their prostate and serum were analyzed. Compared to the finasteride group as positive group, the curcumin group showed similarly protective effect on BPH in histopathologic morphology, prostate volume. Results of immunohistochemistry and western-blot showed decreased expressions of VEGF, TGF-ß1, and IGF1 were also decreased in the curcumin group. These results suggested that curcumin inhibited the development of BPH and might a useful herbal treatment or functional food for BPH.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 20%
Student > Bachelor 4 20%
Student > Master 4 20%
Student > Doctoral Student 3 15%
Lecturer 1 5%
Other 3 15%
Unknown 1 5%
Readers by discipline Count As %
Medicine and Dentistry 9 45%
Pharmacology, Toxicology and Pharmaceutical Science 4 20%
Nursing and Health Professions 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Agricultural and Biological Sciences 1 5%
Other 2 10%
Unknown 2 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2020.
All research outputs
#2,559,746
of 15,348,605 outputs
Outputs from BMC Complementary and Alternative Medicine
#559
of 2,963 outputs
Outputs of similar age
#54,774
of 286,012 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#57
of 340 outputs
Altmetric has tracked 15,348,605 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,963 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,012 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 340 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.