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Efectos en ratas de los alcoholes de cera de abejas (D-002) sobre la colitis ulcerativa inducida por sulfato de dextrano y etanol

Overview of attention for article published in Revista Peruana de Medicina Experimental y Salud Pública, June 2017
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Title
Efectos en ratas de los alcoholes de cera de abejas (D-002) sobre la colitis ulcerativa inducida por sulfato de dextrano y etanol
Published in
Revista Peruana de Medicina Experimental y Salud Pública, June 2017
DOI 10.17843/rpmesp.2017.342.2369
Pubmed ID
Authors

Vivian Molina-Cuevas, Yazmin Ravelo-Calzado, Zullyt Zamora-Rodríguez, Miriam Noa-Puig, Maikel Valle-Clara, Yohani Pérez-Guerra, Ámbar Oyarzabal-Yera, Sonia Jiménez-Despaigne, Rosa Mas-Ferreiro

Abstract

To investigate the effects of D-002, a mixture of 6 high molecular weight primary aliphatic alcohols, obtained from beeswax (Apis mellifera), on severe inflammatory ulcerative colitis (UC) induced by Dextran sulfate (DSS) and ethanol in rats (Ratus ratus). Rats were randomly distributed in six groups: a zero control to which no damage was caused, and five to which the UC was induced: a negative control (vehicle), three treated with D-002 (25, 100 and 400 mg/kg) and a positive control with sulfasalazine (200 mg/kg) (reference substance). Clinical manifestations (body weight variation, diarrhea and rectal bleeding), macroscopic and histological damage score, and myeloperoxidase (MPO) activity were quantified. The oral treatment with D-002 (25, 100 and 400 mg/ kg) significantly prevented the decrease in body weight. The dose of 400 mg/kg reduced the presence of diarrhea and rectal bleeding, although its comparison with the negative control only reached statistical significance on diarrhea. D-002 (25, 100 and 400 mg/kg) significantly reduced the score of macroscopic lesions (40.0; 43.3 and 47.2% inhibition, respectively), the histological damage score (31.5; 53.7 and 67.1% inhibition, respectively) and the activity of MPO (73.2; 83.6 and 85.0% inhibition, respectively), compared to the negative control group. Sulfasalazine significantly reduced all variables studied. D-002 (25, 100 and 400 mg/kg) significantly protected the colonic mucosa in rats with severe inflammatory UC induced by DSS and ethanol.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 17%
Professor > Associate Professor 1 17%
Researcher 1 17%
Student > Postgraduate 1 17%
Unknown 2 33%
Readers by discipline Count As %
Medicine and Dentistry 2 33%
Agricultural and Biological Sciences 1 17%
Unknown 3 50%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2018.
All research outputs
#17,433,330
of 21,571,428 outputs
Outputs from Revista Peruana de Medicina Experimental y Salud Pública
#50
of 76 outputs
Outputs of similar age
#228,335
of 299,516 outputs
Outputs of similar age from Revista Peruana de Medicina Experimental y Salud Pública
#1
of 1 outputs
Altmetric has tracked 21,571,428 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 76 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,516 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them