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Coronavirus pathogenesis.

Overview of attention for chapter
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#15 of 228)
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

1 news outlet
1 blog
9 tweeters
3 Wikipedia pages


244 Dimensions

Readers on

696 Mendeley
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Chapter title
Coronavirus pathogenesis.
Published in
Advances in Virus Research, January 2011
DOI 10.1016/b978-0-12-385885-6.00009-2
Pubmed ID
Book ISBNs

Weiss SR, Leibowitz JL, Susan R. Weiss, Julian L. Leibowitz, Susan R Weiss, Julian L Leibowitz


Coronaviruses infect many species of animals including humans, causing acute and chronic diseases. This review focuses primarily on the pathogenesis of murine coronavirus mouse hepatitis virus (MHV) and severe acute respiratory coronavirus (SARS-CoV). MHV is a collection of strains, which provide models systems for the study of viral tropism and pathogenesis in several organs systems, including the central nervous system, the liver, and the lung, and has been cited as providing one of the few animal models for the study of chronic demyelinating diseases such as multiple sclerosis. SARS-CoV emerged in the human population in China in 2002, causing a worldwide epidemic with severe morbidity and high mortality rates, particularly in older individuals. We review the pathogenesis of both viruses and the several reverse genetics systems that made much of these studies possible. We also review the functions of coronavirus proteins, structural, enzymatic, and accessory, with an emphasis on roles in pathogenesis. Structural proteins in addition to their roles in virion structure and morphogenesis also contribute significantly to viral spread in vivo and in antagonizing host cell responses. Nonstructural proteins include the small accessory proteins that are not at all conserved between MHV and SARS-CoV and the 16 conserved proteins encoded in the replicase locus, many of which have enzymatic activities in RNA metabolism or protein processing in addition to functions in antagonizing host response.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 696 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Unknown 694 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 105 15%
Student > Master 85 12%
Student > Ph. D. Student 79 11%
Researcher 65 9%
Student > Doctoral Student 42 6%
Other 150 22%
Unknown 170 24%
Readers by discipline Count As %
Medicine and Dentistry 139 20%
Biochemistry, Genetics and Molecular Biology 95 14%
Agricultural and Biological Sciences 53 8%
Immunology and Microbiology 36 5%
Pharmacology, Toxicology and Pharmaceutical Science 32 5%
Other 136 20%
Unknown 205 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2020.
All research outputs
of 16,071,681 outputs
Outputs from Advances in Virus Research
of 228 outputs
Outputs of similar age
of 216,878 outputs
Outputs of similar age from Advances in Virus Research
of 11 outputs
Altmetric has tracked 16,071,681 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 228 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 216,878 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.