↓ Skip to main content

Anti-apoptotic effect of HCV core gene of genotype 3a in Huh-7 cell line

Overview of attention for article published in Virology Journal, November 2011
Altmetric Badge

Citations

dimensions_citation
10 Dimensions

Readers on

mendeley
20 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Anti-apoptotic effect of HCV core gene of genotype 3a in Huh-7 cell line
Published in
Virology Journal, November 2011
DOI 10.1186/1743-422x-8-522
Pubmed ID
Authors

Shah Jahan, Saba Khaliq, Muhammad Hassan Siddiqi, Bushra Ijaz, Waqar Ahmad, Usman A Ashfaq, Sajida Hassan

Abstract

Hepatitis C virus (HCV) Core protein regulates multiple signaling pathways and alters cellular genes expression responsible for HCV induced pathogenesis leading to hepatocellular carcinoma (HCC). Prevalence of HCV genotype 3a associated HCC is higher in Pakistan as compare to the rest of world; however the molecular mechanism behind this is still unclear. This study has been designed to evaluate the effect of HCV core 3a on apoptosis and cell proliferation which are involved in HCC METHODOLOGY: We examined the in vitro effect of HCV Core protein of genotype 3a and 1a on cellular genes involved in apoptosis by Real time PCR in liver cell line (Huh-7). We analyzed the effect of HCV core of genotype 1a and 3a on cell proliferation by MTT assay and on phosphrylation of Akt by western blotting in Huh-7 cells.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ireland 1 5%
Unknown 19 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 30%
Researcher 4 20%
Unspecified 3 15%
Student > Bachelor 2 10%
Student > Master 2 10%
Other 3 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 35%
Unspecified 5 25%
Medicine and Dentistry 4 20%
Environmental Science 1 5%
Immunology and Microbiology 1 5%
Other 2 10%