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Antibody Evasion by a Gammaherpesvirus O-Glycan Shield

Overview of attention for article published in PLoS Pathogens, November 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

blogs
1 blog

Citations

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21 Dimensions

Readers on

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31 Mendeley
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Title
Antibody Evasion by a Gammaherpesvirus O-Glycan Shield
Published in
PLoS Pathogens, November 2011
DOI 10.1371/journal.ppat.1002387
Pubmed ID
Authors

Bénédicte Machiels, Céline Lété, Antoine Guillaume, Jan Mast, Philip G. Stevenson, Alain Vanderplasschen, Laurent Gillet, Machiels B, Lété C, Guillaume A, Mast J, Stevenson PG, Vanderplasschen A, Gillet L, Blossom Damania

Abstract

All gammaherpesviruses encode a major glycoprotein homologous to the Epstein-Barr virus gp350. These glycoproteins are often involved in cell binding, and some provide neutralization targets. However, the capacity of gammaherpesviruses for long-term transmission from immune hosts implies that in vivo neutralization is incomplete. In this study, we used Bovine Herpesvirus 4 (BoHV-4) to determine how its gp350 homolog--gp180--contributes to virus replication and neutralization. A lack of gp180 had no impact on the establishment and maintenance of BoHV-4 latency, but markedly sensitized virions to neutralization by immune sera. Antibody had greater access to gB, gH and gL on gp180-deficient virions, including neutralization epitopes. Gp180 appears to be highly O-glycosylated, and removing O-linked glycans from virions also sensitized them to neutralization. It therefore appeared that gp180 provides part of a glycan shield for otherwise vulnerable viral epitopes. Interestingly, this O-glycan shield could be exploited for neutralization by lectins and carbohydrate-specific antibody. The conservation of O-glycosylation sites in all gp350 homologs suggests that this is a general evasion mechanism that may also provide a therapeutic target.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
Norway 1 3%
Unknown 29 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 32%
Student > Master 5 16%
Researcher 4 13%
Professor 3 10%
Student > Bachelor 2 6%
Other 7 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 48%
Immunology and Microbiology 5 16%
Veterinary Science and Veterinary Medicine 3 10%
Biochemistry, Genetics and Molecular Biology 2 6%
Unspecified 2 6%
Other 4 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 November 2011.
All research outputs
#754,413
of 4,681,522 outputs
Outputs from PLoS Pathogens
#1,248
of 3,625 outputs
Outputs of similar age
#34,542
of 230,133 outputs
Outputs of similar age from PLoS Pathogens
#40
of 138 outputs
Altmetric has tracked 4,681,522 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,625 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.7. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,133 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 138 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.