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Current understanding of hepatic and intestinal OATP-mediated drug–drug interactions

Overview of attention for article published in Expert Review of Clinical Pharmacology, January 2014
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  • Above-average Attention Score compared to outputs of the same age (62nd percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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2 tweeters

Citations

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30 Dimensions

Readers on

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21 Mendeley
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Title
Current understanding of hepatic and intestinal OATP-mediated drug–drug interactions
Published in
Expert Review of Clinical Pharmacology, January 2014
DOI 10.1586/ecp.11.58
Pubmed ID
Authors

Anna Koenen, Heyo K Kroemer, Markus Grube, Henriette E Meyer zu Schwabedissen

Abstract

At present, many patients are medicated with various drugs, which are, at the same time, associated with an increased risk of drug-drug interactions (DDIs). Detailed analysis of mechanisms underlying DDIs is the basis of a better prediction of adverse drug events caused by drug interactions. In the last few decades, an involvement of transporters in such processes has been more and more recognized. Indeed, uptake transporters belonging to the organic anion-transporting polypeptide (OATP) family have been shown to interact with a variety of drugs in clinical use. Particularly, the subfamily of OATP1B transporters has been extensively studied, identifying several clinical significant DDIs based on those hepatic uptake transporters. By contrast, the role of OATP2B1 in this context is rather underestimated. Therefore, in addition to known interactions based on OATP1B transporters, we have focused on DDIs probably based on OATP2B1 inhibition in the liver and those possibly owing to the inhibition of OATP2B1-mediated drug absorption in the intestine.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 19%
Researcher 3 14%
Unspecified 3 14%
Other 3 14%
Student > Postgraduate 2 10%
Other 6 29%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 5 24%
Medicine and Dentistry 3 14%
Agricultural and Biological Sciences 3 14%
Biochemistry, Genetics and Molecular Biology 3 14%
Unspecified 3 14%
Other 4 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 November 2011.
All research outputs
#1,989,412
of 4,507,072 outputs
Outputs from Expert Review of Clinical Pharmacology
#55
of 150 outputs
Outputs of similar age
#78,665
of 229,657 outputs
Outputs of similar age from Expert Review of Clinical Pharmacology
#5
of 10 outputs
Altmetric has tracked 4,507,072 research outputs across all sources so far. This one has received more attention than most of these and is in the 53rd percentile.
So far Altmetric has tracked 150 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,657 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.