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Polymorphisms in early neurodevelopmental genes affect natural variation in alcohol sensitivity in adult drosophila

Overview of attention for article published in BMC Genomics, October 2015
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  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

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10 tweeters
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1 Facebook page

Citations

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26 Dimensions

Readers on

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48 Mendeley
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1 CiteULike
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Title
Polymorphisms in early neurodevelopmental genes affect natural variation in alcohol sensitivity in adult drosophila
Published in
BMC Genomics, October 2015
DOI 10.1186/s12864-015-2064-5
Pubmed ID
Authors

Tatiana V. Morozova, Wen Huang, Victoria A. Pray, Thomas Whitham, Robert R. H. Anholt, Trudy F. C. Mackay

Abstract

Alcohol abuse and alcoholism are significant public health problems, but the genetic basis for individual variation in alcohol sensitivity remains poorly understood. Drosophila melanogaster presents a powerful model system for dissecting the genetic underpinnings that determine individual variation in alcohol-related phenotypes. We performed genome wide association analyses for alcohol sensitivity using the sequenced, inbred lines of the D. melanogaster Genetic Reference Panel (DGRP) together with extreme QTL mapping in an advanced intercross population derived from sensitive and resistant DGRP lines. The DGRP harbors substantial genetic variation for alcohol sensitivity and tolerance. We identified 247 candidate genes affecting alcohol sensitivity in the DGRP or the DGRP-derived advanced intercross population, some of which met a Bonferroni-corrected significance threshold, while others occurred among the top candidate genes associated with variation in alcohol sensitivity in multiple analyses. Among these were candidate genes associated with development and function of the nervous system, including several genes in the Dopamine decarboxylase (Ddc) cluster involved in catecholamine synthesis. We found that 58 of these genes formed a genetic interaction network. We verified candidate genes using mutational analysis, targeted gene disruption through RNAi knock-down and transcriptional profiling. Two-thirds of the candidate genes have been implicated in previous Drosophila, mouse and human studies of alcohol-related phenotypes. Individual variation in alcohol sensitivity in Drosophila is highly polygenic and in part determined by variation in evolutionarily conserved signaling pathways that are associated with catecholamine neurotransmitter biosynthesis and early development of the nervous system.

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 47 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 27%
Researcher 13 27%
Student > Bachelor 5 10%
Student > Master 4 8%
Student > Doctoral Student 3 6%
Other 10 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 44%
Biochemistry, Genetics and Molecular Biology 11 23%
Psychology 4 8%
Unspecified 3 6%
Neuroscience 3 6%
Other 6 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2016.
All research outputs
#3,391,687
of 13,533,030 outputs
Outputs from BMC Genomics
#1,807
of 7,919 outputs
Outputs of similar age
#70,630
of 282,910 outputs
Outputs of similar age from BMC Genomics
#219
of 992 outputs
Altmetric has tracked 13,533,030 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 7,919 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,910 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 992 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.