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MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1α

Overview of attention for article published in Journal of Inflammation, August 2018
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Title
MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1α
Published in
Journal of Inflammation, August 2018
DOI 10.1186/s12950-018-0191-x
Pubmed ID
Authors

Li Xu, Wen J. Sun, Ai J. Jia, Lu L. Qiu, Bing Xiao, Lin Mu, Jian M. Li, Xiu F. Zhang, Yan Wei, Cong Peng, Dong S. Zhang, Xu D. Xiang

Abstract

T helper 17 (Th17) cells have proven to be crucial in the pathogenesis of neutrophils-dominant asthma. Hypoxia inducible factor-1α (HIF-1α) is involved in allergic responses in asthma. Our previous studies indicated that Methtyl-CpG binding domain protein 2 (MBD2) expression was increased in asthma patients. The aim of the present study is to understand how MBD2 interacts with HIF-1α to regulate Th17 cell differentiation and IL-17 expression in neutrophils-dominant asthma. A neutrophils-dominant asthma mouse model was established using female C57BL/6 mice to investigate Th17 cell differentiation and MBD2 and HIF-1α expression regulation using flow cytometry, western blot or qRT-PCR. MBD2 and HIF-1α genes were silenced or overexpressed through lentiviral transduction to explore the roles of MBD2 in Th17 cell differentiation and IL-17 release in neutrophils-dominant asthma. A neutrophilic inflammatory asthma phenotype model was established successfully. This was characterized by airway hyperresponsiveness (AHR), increased BALF neutrophil granulocytes, activated Th17 cell differentiation, and high IL-17 levels. MBD2 and HIF-1α expression were significantly increased in the lung and spleen cells of mice with neutrophils-dominant asthma. Through overexpression or silencing of MBD2 and HIF-1α genes, we have concluded that MBD2 and HIF-1α regulate Th17 cell differentiation and IL-17 secretion. Moreover, MBD2 was also found to regulate HIF-1α expression. Our findings have uncovered new roles for MBD2 and HIF-1α, and provide novel insights into the epigenetic regulation of neutrophils-dominant asthma.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 25%
Student > Master 3 25%
Researcher 3 25%
Other 1 8%
Unknown 2 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 33%
Agricultural and Biological Sciences 2 17%
Immunology and Microbiology 2 17%
Medicine and Dentistry 1 8%
Unknown 3 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2018.
All research outputs
#10,221,222
of 13,401,480 outputs
Outputs from Journal of Inflammation
#152
of 269 outputs
Outputs of similar age
#185,073
of 268,019 outputs
Outputs of similar age from Journal of Inflammation
#1
of 1 outputs
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So far Altmetric has tracked 269 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
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