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Epigenome-Wide Association Study of Tic Disorders

Overview of attention for article published in Twin Research & Human Genetics, October 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

blogs
1 blog
twitter
3 tweeters

Citations

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20 Dimensions

Readers on

mendeley
34 Mendeley
Title
Epigenome-Wide Association Study of Tic Disorders
Published in
Twin Research & Human Genetics, October 2015
DOI 10.1017/thg.2015.72
Pubmed ID
Authors

Nuno R. Zilhão, Shanmukha S. Padmanabhuni, Luca Pagliaroli, Csaba Barta, Dirk J. A. Smit, Danielle Cath, Michel G. Nivard, Bart M. L. Baselmans, Jenny van Dongen, Peristera Paschou, Dorret I. Boomsma

Abstract

Tic disorders are moderately heritable common psychiatric disorders that can be highly troubling, both in childhood and in adulthood. In this study, we report results obtained in the first epigenome-wide association study (EWAS) of tic disorders. The subjects are participants in surveys at the Netherlands Twin Register (NTR) and the NTR biobank project. Tic disorders were measured with a self-report version of the Yale Global Tic Severity Scale Abbreviated version (YGTSS-ABBR), included in the 8th wave NTR data collection (2008). DNA methylation data consisted of 411,169 autosomal methylation sites assessed by the Illumina Infinium HumanMethylation450 BeadChip Kit (HM450k array). Phenotype and DNA methylation data were available in 1,678 subjects (mean age = 41.5). No probes reached genome-wide significance (p < 1.2 × 10-7). The strongest associated probe was cg15583738, located in an intergenic region on chromosome 8 (p = 1.98 × 10-6). Several of the top ranking probes (p < 1 × 10-4) were in or nearby genes previously associated with neurological disorders (e.g., GABBRI, BLM, and ADAM10), warranting their further investigation in relation to tic disorders. The top significantly enriched gene ontology (GO) terms among higher ranking methylation sites included anatomical structure morphogenesis (GO:0009653, p = 4.6 × 10-15) developmental process (GO:0032502, p = 2.96 × 10-12), and cellular developmental process (GO:0048869, p = 1.96 × 10-12). Overall, these results provide a first insight into the epigenetic mechanisms of tic disorders. This first study assesses the role of DNA methylation in tic disorders, and it lays the foundations for future work aiming to unravel the biological mechanisms underlying the architecture of this disorder.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 41%
Student > Master 4 12%
Student > Postgraduate 3 9%
Student > Bachelor 3 9%
Researcher 3 9%
Other 6 18%
Unknown 1 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 47%
Medicine and Dentistry 5 15%
Biochemistry, Genetics and Molecular Biology 3 9%
Neuroscience 3 9%
Psychology 2 6%
Other 1 3%
Unknown 4 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2016.
All research outputs
#1,707,023
of 12,010,397 outputs
Outputs from Twin Research & Human Genetics
#72
of 418 outputs
Outputs of similar age
#45,432
of 252,828 outputs
Outputs of similar age from Twin Research & Human Genetics
#7
of 17 outputs
Altmetric has tracked 12,010,397 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 418 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,828 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.