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Gut microbiota and sirtuins in obesity-related inflammation and bowel dysfunction

Overview of attention for article published in Journal of Translational Medicine, November 2011
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Mentioned by

twitter
3 tweeters

Citations

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19 Dimensions

Readers on

mendeley
145 Mendeley
citeulike
1 CiteULike
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Title
Gut microbiota and sirtuins in obesity-related inflammation and bowel dysfunction
Published in
Journal of Translational Medicine, November 2011
DOI 10.1186/1479-5876-9-202
Pubmed ID
Authors

Shaheen E Lakhan, Annette Kirchgessner

Abstract

Obesity is a chronic disease characterized by persistent low-grade inflammation with alterations in gut motility. Motor abnormalities suggest that obesity has effects on the enteric nervous system (ENS), which controls virtually all gut functions. Recent studies have revealed that the gut microbiota can affect obesity and increase inflammatory tone by modulating mucosal barrier function. Furthermore, the observation that inflammatory conditions influence the excitability of enteric neurons may add to the gut dysfunction in obesity. In this article, we discuss recent advances in understanding the role of gut microbiota and inflammation in the pathogenesis of obesity and obesity-related gastrointestinal dysfunction. The potential contribution of sirtuins in protecting or regulating the circuitry of the ENS under inflamed states is also considered.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 145 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Malaysia 1 <1%
France 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 140 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 27 19%
Student > Bachelor 24 17%
Student > Ph. D. Student 21 14%
Student > Master 16 11%
Other 10 7%
Other 25 17%
Unknown 22 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 54 37%
Medicine and Dentistry 19 13%
Biochemistry, Genetics and Molecular Biology 15 10%
Immunology and Microbiology 9 6%
Pharmacology, Toxicology and Pharmaceutical Science 4 3%
Other 17 12%
Unknown 27 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2011.
All research outputs
#13,824,392
of 22,154,328 outputs
Outputs from Journal of Translational Medicine
#1,709
of 3,843 outputs
Outputs of similar age
#155,607
of 249,961 outputs
Outputs of similar age from Journal of Translational Medicine
#88
of 125 outputs
Altmetric has tracked 22,154,328 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,843 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,961 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 125 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.