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Antiparasitic activity of chicory (Cichorium intybus) and its natural bioactive compounds in livestock: a review

Overview of attention for article published in Parasites & Vectors, August 2018
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  • Above-average Attention Score compared to outputs of the same age (58th percentile)

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4 tweeters
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Citations

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5 Dimensions

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41 Mendeley
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Title
Antiparasitic activity of chicory (Cichorium intybus) and its natural bioactive compounds in livestock: a review
Published in
Parasites & Vectors, August 2018
DOI 10.1186/s13071-018-3012-4
Pubmed ID
Authors

Miguel Peña-Espinoza, Angela H. Valente, Stig M. Thamsborg, Henrik T. Simonsen, Ulrik Boas, Heidi L. Enemark, Rodrigo López-Muñoz, Andrew R. Williams

Abstract

Increasing drug resistance in gastrointestinal (GI) parasites of livestock and concerns about chemical residues in animal products and the environment are driving the development of alternative control strategies that are less reliant on the use of synthetic drugs. An increasingly investigated approach is the use of bioactive forages with antiparasitic properties as part of the animal's diet (nutraceuticals) or as potential sources of novel, natural parasiticides. Chicory (Cichorium intybus) is a multi-purpose crop and one of the most promising bioactive forages in temperate regions, and numerous in vivo trials have explored its potential against parasitic nematodes in livestock. However, it is unclear whether chicory can induce a direct and broad activity against various GI parasites in different livestock species, and the levels of chicory in the diet that are required to exert an efficient antiparasitic effect. Moreover, the mechanisms leading to the reported parasiticidal activity of chicory are still largely unknown, and its bioactive phytochemicals have only recently been investigated. In this review, we summarise the progress in the study of the antiparasitic activity of chicory and its natural bioactive compounds against GI parasites in livestock, through examination of the published literature. The available evidence indicates that feeding chicory can reduce faecal egg counts and/or worm burdens of abomasal nematodes, but not infections with intestinal worms, in ruminants. Highly chicory-rich diets (≥ 70% of chicory dry matter in the diet) may be necessary to directly affect abomasal parasitism. Chicory is known to synthesise several bioactive compounds with potential antiparasitic activity, but most research has been devoted to the role of sesquiterpene lactones (SL). Recent in vitro studies have confirmed direct and potent activity of SL-rich extracts from chicory against different GI helminths of livestock. Chicory SL have also been reported to exhibit antimalarial properties and its potential antiprotozoal activity in livestock remains to be evaluated. Furthermore, the detailed identification of the main antiparasitic metabolites of chicory and their pharmacokinetics need further confirmation. Research gaps and perspectives on the potential use of chicory as a nutraceutical forage and a source of bioactive compounds for parasite control in livestock are discussed.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 9 22%
Student > Bachelor 7 17%
Researcher 5 12%
Student > Master 4 10%
Student > Ph. D. Student 4 10%
Other 6 15%
Unknown 6 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 29%
Veterinary Science and Veterinary Medicine 9 22%
Biochemistry, Genetics and Molecular Biology 3 7%
Nursing and Health Professions 2 5%
Medicine and Dentistry 2 5%
Other 2 5%
Unknown 11 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2020.
All research outputs
#7,872,395
of 15,306,165 outputs
Outputs from Parasites & Vectors
#1,361
of 4,119 outputs
Outputs of similar age
#112,284
of 277,123 outputs
Outputs of similar age from Parasites & Vectors
#1
of 1 outputs
Altmetric has tracked 15,306,165 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,119 research outputs from this source. They receive a mean Attention Score of 4.6. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,123 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them