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Antineutrophil cytoplasmic antibodies in Chinese patients with tuberculosis

Overview of attention for article published in Revista da Sociedade Brasileira de Medicina Tropical, August 2018
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Title
Antineutrophil cytoplasmic antibodies in Chinese patients with tuberculosis
Published in
Revista da Sociedade Brasileira de Medicina Tropical, August 2018
DOI 10.1590/0037-8682-0400-2017
Pubmed ID
Authors

Gao Huan, Gao Yang, Qu Xiao-yu, Xu Jiancheng, Song Yan-qing

Abstract

Based on reports, infection with Mycobacterium tuberculosis is believed to induce the development of antibodies that are considered to be biological indicators for the diagnosis of some other diseases. However, conflicting results have been published regarding the presence of antineutrophil cytoplasmic antibodies (ANCAs) in patients with tuberculosis. We aim to study the seroprevalence of ANCA in a population of Chinese patients with tuberculosis, which may lead to the misdiagnosis of vasculitic disorders. The study was conducted from January 2016 to May 2017 to evaluate the presence of ANCA in 103 Chinese patients using indirect immunofluorescent assay. An enzyme-linked immunosorbent assay was performed for anti-myeloperoxidase (MPO) and anti-proteinase 3 (PR3) detection. Perinuclear ANCA (p-ANCA) was detected in 4.8% (5/103) of patients, whereas cytoplasmic ANCA (c-ANCA) was not detected; 1.9% (2/103) of patients with tuberculosis was positive for anti-MPO antibodies, and none had anti-PR3 antibodies. Both anti-MPO-positive patients were diagnosed with ANCA-associated vasculitides. ANCA positivity may be more related to vasculitis and immunological disorders than to a M. tuberculosis infection. Therefore, to improve diagnostic accuracy, patients with M. tuberculosis who are ANCA positive should be investigated for concurrent diseases, including the effects of drugs. Therefore, even in tuberculosis epidemic area, ANCA seropositivity, detected by ELISA, is still more suggestive of ANCA-associated vasculitides.

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Mendeley readers

The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 126 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 4 3%
Student > Bachelor 3 2%
Researcher 1 <1%
Student > Ph. D. Student 1 <1%
Unknown 117 93%
Readers by discipline Count As %
Medicine and Dentistry 6 5%
Biochemistry, Genetics and Molecular Biology 1 <1%
Engineering 1 <1%
Unknown 118 94%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2018.
All research outputs
#14,033,804
of 15,915,110 outputs
Outputs from Revista da Sociedade Brasileira de Medicina Tropical
#239
of 325 outputs
Outputs of similar age
#238,896
of 279,036 outputs
Outputs of similar age from Revista da Sociedade Brasileira de Medicina Tropical
#1
of 1 outputs
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So far Altmetric has tracked 325 research outputs from this source. They receive a mean Attention Score of 1.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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