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Mortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis

Overview of attention for article published in Revista da Sociedade Brasileira de Medicina Tropical, August 2018
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3 tweeters

Citations

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12 Dimensions

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50 Mendeley
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Title
Mortality in patients with multidrug-resistant Pseudomonas aeruginosa infections: a meta-analysis
Published in
Revista da Sociedade Brasileira de Medicina Tropical, August 2018
DOI 10.1590/0037-8682-0506-2017
Pubmed ID
Authors

Eliseth Costa Oliveira de Matos, Regis Bruni Andriolo, Yan Corrêa Rodrigues, Patrícia Danielle Lima de Lima, Irna Carla do Rosário Souza Carneiro, Karla Valéria Batista Lima

Abstract

Pseudomonas aeruginosa is the leading cause of nosocomial infections with high mortality rates owing to the limited therapeutic options for multidrug-resistant Pseudomonas aeruginosa (MDRPA) and metallo-beta-lactamase (MBL)-producing strains. Herein, we present a meta-analysis exploring the association between MDRPA and São Paulo MBL-1 (SPM-1)-producing strains vs. mortality. Online databases were screened to identify studies published between 2006 and 2016. A total of 15 studies, comprising 3,201 cases of P. aeruginosa infection, were included. Our results demonstrated a higher mortality rate among patients infected with MDRPA (44.6%, 363/813) than those with non-MDRPA infection (24.8%, 593/2,388) [odds ratio (OR) 2.39, 95% confidence interval (CI) 1.70-3.36, p <0.00001]. The risk of mortality in patients with non-SPM-1 strains was four times higher than that observed in the patients of the SPM-1 group; however, no statistically significant difference was observed (p = 0.43). In conclusion, the results of our study demonstrated that patients infected with MDRPA had a significantly higher mortality rate than that of patients infected with non-MDRPA strains, especially patients with bloodstream infection (BSI), immunosuppression, and inadequate antimicrobial therapy. The absence of studies on the molecular aspects of blaSPM-1 and its association with mortality limited the analysis; therefore, our results should be interpreted with caution. Our findings also highlight the need for more studies on the molecular aspects of resistance and the peculiarities of different nosocomial settings.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 50 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 20%
Student > Master 7 14%
Researcher 5 10%
Other 3 6%
Student > Ph. D. Student 3 6%
Other 9 18%
Unknown 13 26%
Readers by discipline Count As %
Medicine and Dentistry 14 28%
Biochemistry, Genetics and Molecular Biology 10 20%
Immunology and Microbiology 4 8%
Agricultural and Biological Sciences 4 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Other 4 8%
Unknown 11 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2018.
All research outputs
#8,007,378
of 13,918,259 outputs
Outputs from Revista da Sociedade Brasileira de Medicina Tropical
#55
of 253 outputs
Outputs of similar age
#141,122
of 273,709 outputs
Outputs of similar age from Revista da Sociedade Brasileira de Medicina Tropical
#1
of 1 outputs
Altmetric has tracked 13,918,259 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 253 research outputs from this source. They receive a mean Attention Score of 1.3. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,709 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them