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rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology

Overview of attention for article published in International Journal of Molecular Sciences, August 2018
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3 tweeters

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Readers on

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16 Mendeley
Title
rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology
Published in
International Journal of Molecular Sciences, August 2018
DOI 10.3390/ijms19092473
Pubmed ID
Authors

Linda Kelemen, Madalene Earp, Brooke Fridley, Georgia Chenevix-Trench, Peter Fasching, Matthias Beckmann, Arif Ekici, Alexander Hein, Diether Lambrechts, Sandrina Lambrechts, Els Van Nieuwenhuysen, Ignace Vergote, Mary Rossing, Jennifer Doherty, Jenny Chang-Claude, Sabine Behrens, Kirsten Moysich, Rikki Cannioto, Shashikant Lele, Kunle Odunsi, Marc Goodman, Yurii Shvetsov, Pamela Thompson, Lynne Wilkens, Thilo Dörk, Natalia Antonenkova, Natalia Bogdanova, Peter Hillemanns, Ingo Runnebaum, Andreas du Bois, Philipp Harter, Florian Heitz, Ira Schwaab, Ralf Butzow, Liisa Pelttari, Heli Nevanlinna, Francesmary Modugno, Robert Edwards, Joseph Kelley, Roberta Ness, Beth Karlan, Jenny Lester, Sandra Orsulic, Christine Walsh, Susanne Kjaer, Allan Jensen, Julie Cunningham, Robert Vierkant, Graham Giles, Fiona Bruinsma, Melissa Southey, Michelle Hildebrandt, Dong Liang, Karen Lu, Xifeng Wu, Thomas Sellers, Douglas Levine, Joellen Schildkraut, Edwin Iversen, Kathryn Terry, Daniel Cramer, Shelley Tworoger, Elizabeth Poole, Elisa Bandera, Sara Olson, Irene Orlow, Liv Vestrheim Thomsen, Line Bjorge, Camilla Krakstad, Ingvild Tangen, Lambertus Kiemeney, Katja Aben, Leon Massuger, Anne van Altena, Tanja Pejovic, Yukie Bean, Melissa Kellar, Linda Cook, Nhu Le, Angela Brooks-Wilson, Jacek Gronwald, Cezary Cybulski, Anna Jakubowska, Jan Lubiński, Nicolas Wentzensen, Louise Brinton, Jolanta Lissowska, Estrid Hogdall, Svend Engelholm, Claus Hogdall, Lene Lundvall, Lotte Nedergaard, Paul Pharoah, Ed Dicks, Honglin Song, Jonathan Tyrer, Iain McNeish, Nadeem Siddiqui, Karen Carty, Rosalind Glasspool, James Paul, Ian Campbell, Diana Eccles, Alice Whittemore, Valerie McGuire, Joseph Rothstein, Weiva Sieh, Steven Narod, Catherine Phelan, John McLaughlin, Harvey Risch, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Simon Gayther, Aleksandra Gentry-Maharaj, Susan Ramus, Anna Wu, Celeste Pearce, Alice Lee, Malcolm Pike, Jolanta Kupryjanczyk, Agnieszka Podgorska, Joanna Plisiecka-Halasa, Wlodzimierz Sawicki, Ellen Goode, Andrew Berchuck

Abstract

Thymidylate synthase (TYMS) is a crucial enzyme for DNA synthesis. TYMS expression is regulated by its antisense mRNA, ENOSF1. Disrupted regulation may promote uncontrolled DNA synthesis and tumor growth. We sought to replicate our previously reported association between rs495139 in the TYMS-ENOSF1 3' gene region and increased risk of mucinous ovarian carcinoma (MOC) in an independent sample. Genotypes from 24,351 controls to 15,000 women with invasive OC, including 665 MOC, were available. We estimated per-allele odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression, and meta-analysis when combining these data with our previous report. The association between rs495139 and MOC was not significant in the independent sample (OR = 1.09; 95% CI = 0.97⁻1.22; p = 0.15; N = 665 cases). Meta-analysis suggested a weak association (OR = 1.13; 95% CI = 1.03⁻1.24; p = 0.01; N = 1019 cases). No significant association with risk of other OC histologic types was observed (p = 0.05 for tumor heterogeneity). In expression quantitative trait locus (eQTL) analysis, the rs495139 allele was positively associated with ENOSF1 mRNA expression in normal tissues of the gastrointestinal system, particularly esophageal mucosa (r = 0.51, p = 1.7 × 10-28), and nonsignificantly in five MOC tumors. The association results, along with inconclusive tumor eQTL findings, suggest that a true effect of rs495139 might be small.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 31%
Researcher 3 19%
Lecturer 1 6%
Librarian 1 6%
Student > Master 1 6%
Other 1 6%
Unknown 4 25%
Readers by discipline Count As %
Medicine and Dentistry 5 31%
Computer Science 1 6%
Mathematics 1 6%
Nursing and Health Professions 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Other 4 25%
Unknown 3 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 August 2018.
All research outputs
#8,411,992
of 13,429,000 outputs
Outputs from International Journal of Molecular Sciences
#4,384
of 10,518 outputs
Outputs of similar age
#160,087
of 267,981 outputs
Outputs of similar age from International Journal of Molecular Sciences
#163
of 467 outputs
Altmetric has tracked 13,429,000 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,518 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,981 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 467 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.