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A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes

Overview of attention for article published in Nutrition & Metabolism, October 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#38 of 760)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

news
7 news outlets
blogs
3 blogs
twitter
31 tweeters
facebook
3 Facebook pages
video
1 video uploader

Readers on

mendeley
129 Mendeley
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Title
A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes
Published in
Nutrition & Metabolism, October 2015
DOI 10.1186/s12986-015-0033-2
Pubmed ID
Authors

Nicola D. Guess, Anne Dornhorst, Nick Oliver, Jimmy D. Bell, E. Louise Thomas, Gary S. Frost

Abstract

Fat infiltration of the liver, muscle and pancreas is associated with insulin resistance and risk of diabetes. Weight loss reduces ectopic fat deposition and risk of diabetes, but is difficult to sustain to due to compensatory increases in appetite. Fermentable carbohydrates have been shown to decrease appetite and food intake, and promote weight loss in overweight subjects. In animal studies, fermentable carbohydrate reduces ectopic fat independent of weight loss. We aimed to investigate the effect of the fermentable carbohydrate inulin on weight maintenance, appetite and ectopic fat in subjects with prediabetes. Forty-four subjects with prediabetes were randomized to 18 weeks' inulin or cellulose supplementation. During weeks 1-9 (weight loss phase) all subjects had four visits with a dietitian to guide them towards a 5 % weight loss. During weeks 10-18 (weight maintenance phase) subjects continued taking their assigned supplementation and were asked to maintain the weight they had lost but were offered no further support. All subjects attended study sessions at baseline, 9 and 18 weeks for measurement of weight; assessment of adipose tissue and ectopic fat content by magnetic resonance imaging and magnetic resonance spectroscopy; glucose, insulin and GLP-1 levels following a meal tolerance test; and appetite by ad libitum meal test and visual analogue scales. Both groups lost approximately 5 % of their body weight by week nine (-5.3 ± 0.1 % vs -4.3 ± 0.4 %, p = 0.13, but the inulin group lost significantly more weight between 9 and 18 weeks (-2.3 ± 0.5 % vs -0.6 ± 0.4 %, p = 0.012). Subjects taking inulin had lower hepatic (p = 0.02) and soleus muscle (p < 0.05) fat content at 18 weeks compared to control even after controlling for weight loss and consumed less at the ad libitum meal test (p = 0.027). Fasting glucose significantly decreased at week nine only (p = 0.005), insulin concentrations did not change, and there was a significant increase in GLP-1 in the cellulose group at 9 and 18 weeks (p < 0.03, p < 0.00001). Inulin may have a two-pronged effect on the risk of diabetes by 1) promoting weight loss 2) reducing intrahepatocellular and intramyocellular lipid in people with prediabetes independent of weight loss. Clinical trial number: NCT01841073.

Twitter Demographics

The data shown below were collected from the profiles of 31 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
United Kingdom 1 <1%
Indonesia 1 <1%
Unknown 125 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 26 20%
Student > Bachelor 21 16%
Student > Ph. D. Student 16 12%
Researcher 13 10%
Other 12 9%
Other 28 22%
Unknown 13 10%
Readers by discipline Count As %
Medicine and Dentistry 38 29%
Agricultural and Biological Sciences 20 16%
Biochemistry, Genetics and Molecular Biology 17 13%
Nursing and Health Professions 16 12%
Immunology and Microbiology 3 2%
Other 18 14%
Unknown 17 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 97. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2020.
All research outputs
#213,299
of 15,557,294 outputs
Outputs from Nutrition & Metabolism
#38
of 760 outputs
Outputs of similar age
#5,579
of 286,594 outputs
Outputs of similar age from Nutrition & Metabolism
#2
of 44 outputs
Altmetric has tracked 15,557,294 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 760 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.2. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,594 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.