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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants
|
|---|---|
| Published in |
BMC Developmental Biology, November 2011
|
| DOI | 10.1186/1471-213x-11-71 |
| Pubmed ID | |
| Authors |
Beata Sapetto-Rebow, Sarah C McLoughlin, Lynne C O'Shea, Olivia O'Leary, Jason R Willer, Yolanda Alvarez, Ross Collery, Jacintha O'Sullivan, Freek Van Eeden, Carmel Hensey, Breandán N Kennedy |
| Abstract |
Genetic alterations in human topoisomerase II alpha (TOP2A) are linked to cancer susceptibility. TOP2A decatenates chromosomes and thus is necessary for multiple aspects of cell division including DNA replication, chromosome condensation and segregation. Topoisomerase II alpha is also required for embryonic development in mammals, as mouse Top2a knockouts result in embryonic lethality as early as the 4-8 cell stage. The purpose of this study was to determine whether the extended developmental capability of zebrafish top2a mutants arises from maternal expression of top2a or compensation from its top2b paralogue. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 3% |
| Unknown | 35 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 19% |
| Student > Ph. D. Student | 7 | 19% |
| Student > Master | 6 | 17% |
| Student > Bachelor | 5 | 14% |
| Student > Postgraduate | 3 | 8% |
| Other | 4 | 11% |
| Unknown | 4 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 19 | 53% |
| Agricultural and Biological Sciences | 6 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Immunology and Microbiology | 1 | 3% |
| Psychology | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 7 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2011.
All research outputs
#18,301,870
of 22,659,164 outputs
Outputs from BMC Developmental Biology
#304
of 369 outputs
Outputs of similar age
#195,452
of 239,459 outputs
Outputs of similar age from BMC Developmental Biology
#9
of 10 outputs
Altmetric has tracked 22,659,164 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 369 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,459 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one.