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Vascularization mediated by mesenchymal stem cells from bone marrow and adipose tissue: a comparison

Overview of attention for article published in Cell Regeneration, January 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (69th percentile)

Mentioned by

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7 tweeters
facebook
1 Facebook page

Readers on

mendeley
112 Mendeley
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Title
Vascularization mediated by mesenchymal stem cells from bone marrow and adipose tissue: a comparison
Published in
Cell Regeneration, January 2015
DOI 10.1186/s13619-015-0025-8
Pubmed ID
Authors

Karoline Pill, Sandra Hofmann, Heinz Redl, Wolfgang Holnthoner

Abstract

Tissue-engineered constructs are promising to overcome shortage of organ donors and to reconstruct at least parts of injured or diseased tissues or organs. However, oxygen and nutrient supply are limiting factors in many tissues, especially after implantation into the host. Therefore, the development of a vascular system prior to implantation appears crucial. To develop a functional vascular system, different cell types that interact with each other need to be co-cultured to simulate a physiological environment in vitro. This review provides an overview and a comparison of the current knowledge of co-cultures of human endothelial cells (ECs) with human adipose tissue-derived stem/stromal cells (ASCs) or bone marrow-mesenchymal stem cells (BMSCs) in three dimensional (3D) hydrogel matrices. Mesenchymal stem cells (MSCs), BMSCs or ASCs, have been shown to enhance vascular tube formation of ECs and to provide a stabilizing function in addition to growth factor delivery and permeability control for ECs. Although phenotypically similar, MSCs from different tissues promote tubulogenesis through distinct mechanisms. In this report, we describe differences and similarities regarding molecular interactions in order to investigate which of these two cell types displays more favorable characteristics to be used in clinical applications. Our comparative study shows that ASCs as well as BMSCs are both promising cell types to induce vascularization with ECs in vitro and consequently are promising candidates to support in vivo vascularization.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 <1%
Austria 1 <1%
Netherlands 1 <1%
Unknown 109 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 26 23%
Student > Ph. D. Student 26 23%
Researcher 17 15%
Student > Bachelor 13 12%
Unspecified 12 11%
Other 18 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 27%
Engineering 23 21%
Medicine and Dentistry 20 18%
Unspecified 18 16%
Biochemistry, Genetics and Molecular Biology 11 10%
Other 10 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2016.
All research outputs
#1,778,668
of 7,408,484 outputs
Outputs from Cell Regeneration
#18
of 35 outputs
Outputs of similar age
#69,428
of 238,328 outputs
Outputs of similar age from Cell Regeneration
#2
of 2 outputs
Altmetric has tracked 7,408,484 research outputs across all sources so far. This one has received more attention than most of these and is in the 62nd percentile.
So far Altmetric has tracked 35 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one scored the same or higher as 17 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,328 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.