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A metabolic signature of long life in Caenorhabditis elegans

Overview of attention for article published in BMC Biology, February 2010
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Title
A metabolic signature of long life in Caenorhabditis elegans
Published in
BMC Biology, February 2010
DOI 10.1186/1741-7007-8-14
Pubmed ID
Authors

Silke Fuchs, Jacob G Bundy, Sarah K Davies, Jonathan M Viney, Jonathan S Swire, Armand M Leroi

Abstract

Many Caenorhabditis elegans mutations increase longevity and much evidence suggests that they do so at least partly via changes in metabolism. However, up until now there has been no systematic investigation of how the metabolic networks of long-lived mutants differ from those of normal worms. Metabolomic technologies, that permit the analysis of many untargeted metabolites in parallel, now make this possible. Here we use one of these, 1H nuclear magnetic resonance spectroscopy, to investigate what makes long-lived worms metabolically distinctive.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 244 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 2%
United Kingdom 3 1%
Belgium 2 <1%
Germany 2 <1%
France 1 <1%
Sweden 1 <1%
Switzerland 1 <1%
Portugal 1 <1%
Greece 1 <1%
Other 1 <1%
Unknown 225 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 75 31%
Researcher 64 26%
Other 12 5%
Professor 12 5%
Student > Bachelor 12 5%
Other 39 16%
Unknown 30 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 110 45%
Biochemistry, Genetics and Molecular Biology 51 21%
Chemistry 15 6%
Medicine and Dentistry 15 6%
Neuroscience 4 2%
Other 17 7%
Unknown 32 13%