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Decline of FOXN1 gene expression in human thymus correlates with age: possible epigenetic regulation.

Overview of attention for article published in Immunity & Ageing, October 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#12 of 117)
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

blogs
2 blogs
twitter
1 tweeter

Citations

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9 Dimensions

Readers on

mendeley
25 Mendeley
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Title
Decline of FOXN1 gene expression in human thymus correlates with age: possible epigenetic regulation.
Published in
Immunity & Ageing, October 2015
DOI 10.1186/s12979-015-0045-9
Pubmed ID
Authors

Maria DS Reis, Krisztian Csomos, Luciene PB Dias, Zsolt Prodan, Tamas Szerafin, Wilson Savino, Laszlo Takacs, Maria Danielma dos Santos Reis, Luciene Paschoal Braga Dias

Abstract

Thymic involution is thought to be an important factor of age related immunodeficiency. Understanding the molecular mechanisms of human thymic senescence may lead to the discovery of novel therapeutic approaches aimed at the reestablishment of central and peripheral T cell repertoire. As an initial approach, here we report that the decline of human thymic FOXN1 transcription correlates with age, while other genes, DLL1, DLL4 and WNT4, essential for thymopoiesis, are constitutively transcribed. Using a human thymic epithelial cell line (hTEC), we show that FOXN1 expression is refractory to signals that induce FOXN1 transcription in primary 3D culture conditions and by stimulation of the canonical WNT signaling pathway. Blockage of FOXN1 induceability in the hTEC line may be mediated by an epigenetic mechanism, the CpG methylation of the FOXN1 gene. We showed a suppression of FOXN1 transcription both in cultured human thymic epithelial cells and in the aging thymus. We hypothesize that the underlying mechanism may be associated with changes of the DNA methylation state of the FOXN1 gene.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 24%
Unspecified 5 20%
Student > Bachelor 4 16%
Researcher 4 16%
Student > Master 3 12%
Other 3 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 44%
Unspecified 5 20%
Biochemistry, Genetics and Molecular Biology 4 16%
Medicine and Dentistry 2 8%
Immunology and Microbiology 1 4%
Other 2 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2015.
All research outputs
#385,920
of 6,585,900 outputs
Outputs from Immunity & Ageing
#12
of 117 outputs
Outputs of similar age
#21,369
of 208,480 outputs
Outputs of similar age from Immunity & Ageing
#2
of 8 outputs
Altmetric has tracked 6,585,900 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 117 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,480 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.