Title |
Phosphorus ingestion improves oral glucose tolerance of healthy male subjects: a crossover experiment
|
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Published in |
Nutrition Journal, October 2015
|
DOI | 10.1186/s12937-015-0101-5 |
Pubmed ID | |
Authors |
May Khattab, Christelle Abi-Rashed, Hala Ghattas, Sani Hlais, Omar Obeid |
Abstract |
Fasting serum phosphorus (P) was reported to be inversely related to serum glucose and insulin, while the impact of P ingestion is not well documented. The effect of P intake with or before glucose ingestion on postprandial glucose and insulin statuses was investigated. Two cross over experiments using healthy male subjects were conducted. Experiment 1: Overnight fasted subjects (n = 7) randomly received: 500 mg of P tablets, glucose (75 g) solution with placebo or 500 mg of P tablets. Experiment 2: Overnight fasted subjects (n = 8) underwent similar procedures to those of experiment 1, except that placebo or 500 mg P tablets were given 60 min prior to glucose ingestion. In both experiments, serum P decreased following glucose ingestion. Co-ingestion of P with glucose improved, at time 60 min, postprandial glucose (P < 0.05), insulin (P < 0.05), and insulin sensitivity index (p < 0.006), while P pre-ingestion failed to exert similar effect. This study suggests that postprandial glucose and insulin are affected by exogenous P supply, especially when co-ingested with glucose. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
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Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 13% |
Researcher | 4 | 13% |
Student > Master | 4 | 13% |
Student > Bachelor | 3 | 10% |
Lecturer | 3 | 10% |
Other | 2 | 6% |
Unknown | 11 | 35% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 5 | 16% |
Nursing and Health Professions | 4 | 13% |
Agricultural and Biological Sciences | 2 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 1 | 3% |
Unknown | 12 | 39% |