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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Host-parasite interaction: changes in human placental gene expression induced by Trypanosoma cruzi
|
|---|---|
| Published in |
Parasites & Vectors, August 2018
|
| DOI | 10.1186/s13071-018-2988-0 |
| Pubmed ID | |
| Authors |
Christian Castillo, Ileana Carrillo, Gabriela Libisch, Natalia Juiz, Alejandro Schijman, Carlos Robello, Ulrike Kemmerling |
| Abstract |
Chagas disease is caused by Trypanosoma cruzi, a parasite endemic to Latin America. Most infections occur in children by vector or congenital transmission. Trypanosoma cruzi establishes a complexity of specific molecular parasite-host cell interactions to invade the host. However, most studies have been mainly focused on the interaction between the parasite and different cell types, but not on the infection and invasion on a tissue level. During congenital transmission, T. cruzi must cross the placental barrier, composed of epithelial and connective tissues, in order to infect the developing fetus. Here we aimed to study the global changes of transcriptome in the placental tissue after a T. cruzi challenge. Strong changes in gene expression profiling were found in the different experimental conditions, involving the reprogramming of gene expression in genes involved in the innate immune response. Trypanosoma cruzi induces strong changes in genes involved in a wide range of pathways, especially those involved in immune response against infections. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 4 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 59 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 19% |
| Student > Postgraduate | 5 | 8% |
| Student > Bachelor | 5 | 8% |
| Student > Doctoral Student | 5 | 8% |
| Student > Master | 5 | 8% |
| Other | 10 | 17% |
| Unknown | 18 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 25% |
| Agricultural and Biological Sciences | 9 | 15% |
| Medicine and Dentistry | 4 | 7% |
| Immunology and Microbiology | 3 | 5% |
| Veterinary Science and Veterinary Medicine | 2 | 3% |
| Other | 4 | 7% |
| Unknown | 22 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 August 2018.
All research outputs
#15,543,612
of 23,100,534 outputs
Outputs from Parasites & Vectors
#3,416
of 5,523 outputs
Outputs of similar age
#211,447
of 334,198 outputs
Outputs of similar age from Parasites & Vectors
#75
of 129 outputs
Altmetric has tracked 23,100,534 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,523 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,198 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 129 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.