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The LINC Complex

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Cover of 'The LINC Complex'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 EM Tomography of Meiotic LINC Complexes
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    Chapter 2 Recombinant Purification of the Periplasmic Portion of the LINC Complex
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    Chapter 3 Analysis of High Molecular Weight Isoforms of Nesprin-1 and Nesprin-2 with Vertical Agarose Gel Electrophoresis
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    Chapter 4 Analysis of Nesprin-2 Interaction with Its Binding Partners and Actin
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    Chapter 5 Interactions of Nesprin-4-Containing LINC Complexes in Outer Hair Cells Explored by BioID
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    Chapter 6 Using Nesprin Tension Sensors to Measure Force on the LINC Complex
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    Chapter 7 Analyzing Mechanotransduction Through the LINC Complex in Isolated Nuclei
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    Chapter 8 Direct Force Probe for Nuclear Mechanics
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    Chapter 9 Centrifugal Displacement of Nuclei in Adherent Cells to Study LINC Complex-Dependent Mechanisms of Homeostatic Nuclear Positioning
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    Chapter 10 Assembly and Use of a Microfluidic Device to Study Cell Migration in Confined Environments
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    Chapter 11 Investigating LINC Complex Protein Homo-oligomerization in the Nuclear Envelopes of Living Cells Using Fluorescence Fluctuation Spectroscopy
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    Chapter 12 Functional Analysis of the Yeast LINC Complex Using Fluctuation Spectroscopy and Super-Resolution Imaging
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    Chapter 13 Genetic Analysis of Nuclear Migration and Anchorage to Study LINC Complexes During Development of Caenorhabditis elegans
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    Chapter 14 High-Resolution Imaging Methods to Analyze LINC Complex Function During Drosophila Muscle Development
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    Chapter 15 Computational Methods for Studying the Plant Nucleus
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    Chapter 16 Investigation of Nuclear Periphery Protein Interactions in Plants Using the Membrane Yeast Two-Hybrid (MbY2H) System
  18. Altmetric Badge
    Chapter 17 Immunolabeling Protocols for Studying Meiosis in Plant Mutants Defective for Nuclear Envelope Components
  19. Altmetric Badge
    Chapter 18 Generation and Analysis of Striated Muscle Selective LINC Complex Protein Mutant Mice
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    Chapter 19 An In Vitro System to Measure the Positioning, Stiffness, and Rupture of the Nucleus in Skeletal Muscle
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    Chapter 20 Functional Analysis of LINC Complexes in the Skin
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    Chapter 21 Detection of SUN1 Splicing Variants at the mRNA and Protein Levels in Cancer
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    Chapter 22 Next-Generation Sequencing and Mutational Analysis: Implications for Genes Encoding LINC Complex Proteins
Attention for Chapter 18: Generation and Analysis of Striated Muscle Selective LINC Complex Protein Mutant Mice
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Chapter title
Generation and Analysis of Striated Muscle Selective LINC Complex Protein Mutant Mice
Chapter number 18
Book title
The LINC Complex
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-8691-0_18
Pubmed ID
Book ISBNs
978-1-4939-8690-3, 978-1-4939-8691-0
Authors

Stroud, Matthew J, Fang, Xi, Veevers, Jennifer, Chen, Ju, Matthew J. Stroud, Xi Fang, Jennifer Veevers, Ju Chen

Abstract

The linker of nucleoskeleton and cytoskeleton (LINC) complex mediates intracellular cross talk between the nucleus and the cytoplasm. In striated muscle, the LINC complex provides structural support to the myocyte nucleus and plays an essential role in regulating gene expression and mechanotransduction. A wide range of cardiac and skeletal myopathies have been linked to mutations in LINC complex proteins. Studies utilizing tissue-specific knockout and mutant mouse models have revealed important insights into the roles of the LINC complex in striated muscle. In this chapter, we describe several feasible approaches for generating striated muscle-specific gene knockout and mutant mouse models to study LINC complex protein function in cardiac and skeletal muscle. The experimental procedures used for phenotyping and analysis of LINC complex knockout mice are also described.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 1 25%
Student > Ph. D. Student 1 25%
Other 1 25%
Student > Master 1 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 50%
Agricultural and Biological Sciences 1 25%
Engineering 1 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2018.
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#11,894,261
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Outputs from Methods in molecular biology
#5,970
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#230,636
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Outputs of similar age from Methods in molecular biology
#1
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