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Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial

Overview of attention for article published in Diabetes, Obesity & Metabolism, October 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

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11 tweeters

Citations

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1 Dimensions

Readers on

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9 Mendeley
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Title
Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial
Published in
Diabetes, Obesity & Metabolism, October 2018
DOI 10.1111/dom.13514
Pubmed ID
Authors

Edward Yu, Miguel Ruiz-Canela, Cristina Razquin, Marta Guasch-Ferré, Estefania Toledo, Dong D. Wang, Christopher Papandreou, Courtney Dennis, Clary Clish, Liming Liang, Monica Bullo, Dolores Corella, Montserrat Fitó, Mario Gutiérrez-Bedmar, José Lapetra, Ramón Estruch, Emilio Ros, Montserrat Cofán, Fernando Arós, Dora Romaguera, Lluis Serra-Majem, Jose V. Sorlí, Jordi Salas-Salvadó, Frank B. Hu, Miguel A. Martínez-González

Abstract

The associations between arginine-based metabolites and incident type 2 diabetes (T2D) are unknown. We employed a case-cohort design nested within the PREDIMED trial to examine six plasma metabolites (arginine, citrulline, ornithine, asymmetric dimethylarginine [ADMA], symmetric dimethylarginine [SDMA], and N-monomethyl-l-arginine [NMMA]) among 892 individuals (251 cases) for associations with incident T2D and insulin resistance. Weighted Cox models with robust variance were used. 1-year changes in arginine (Adjusted HR per SD = 0.68, 95% CI = 0.49, 0.95; Q4 vs. Q1 = 0.46, 95% CI = 0.21, 1.04, p-trend = 0.02) and arginine/ADMA ratio (Adjusted HR per SD = 0.73, 95% CI = 0.51, 1.04; Q4 vs. Q1 = 0.52, 95% CI = 0.22, 1.25, p-trend = 0.04) were associated with lower risk of T2D. Positive changes of citrulline and ornithine, and negative changes in SDMA and arginine/(ornithine+citrulline) were associated with concurrent 1-year changes in HOMA-IR. Individuals in the low fat diet group experienced higher risk of T2D for 1-year changes in NMMA than individuals in Mediterranean diet groups (p-interaction = 0.02). Arginine bioavailability is important in T2D pathophysiology. This article is protected by copyright. All rights reserved.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Lecturer > Senior Lecturer 3 33%
Librarian 2 22%
Student > Bachelor 1 11%
Student > Master 1 11%
Other 1 11%
Other 1 11%
Readers by discipline Count As %
Unspecified 3 33%
Medicine and Dentistry 3 33%
Biochemistry, Genetics and Molecular Biology 2 22%
Nursing and Health Professions 1 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2019.
All research outputs
#1,886,861
of 12,840,983 outputs
Outputs from Diabetes, Obesity & Metabolism
#411
of 1,838 outputs
Outputs of similar age
#59,463
of 265,009 outputs
Outputs of similar age from Diabetes, Obesity & Metabolism
#30
of 90 outputs
Altmetric has tracked 12,840,983 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,838 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 10.0. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,009 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.