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Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

Overview of attention for article published in Molecular Neurodegeneration, November 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)

Mentioned by

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1 news outlet
twitter
2 tweeters

Citations

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104 Dimensions

Readers on

mendeley
158 Mendeley
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Title
Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits
Published in
Molecular Neurodegeneration, November 2015
DOI 10.1186/s13024-015-0056-1
Pubmed ID
Authors

Zhiqiang Xu, Na Xiao, Yali Chen, Huang, Charles Marshall, Junying Gao, Zhiyou Cai, Ting Wu, Gang Hu, Ming Xiao

Abstract

Preventing or reducing amyloid-beta (Aβ) accumulation in the brain is an important therapeutic strategy for Alzheimer's disease (AD). Recent studies showed that the water channel aquaporin-4 (AQP4) mediates soluble Aβ clearance from the brain parenchyma along the paravascular pathway. However the direct evidence for roles of AQP4 in the pathophysiology of AD remains absent. Here, we reported that the deletion of AQP4 exacerbated cognitive deficits of 12-moth old APP/PS1 mice, with increases in Aβ accumulation, cerebral amyloid angiopathy and loss of synaptic protein and brain-derived neurotrophic factor in the hippocampus and cortex. Furthermore, AQP4 deficiency increased atrophy of astrocytes with significant decreases in interleukin-1 beta and nonsignficant decreases in interleukin-6 and tumor necrosis factor-alpha in hippocampal and cerebral samples. These results suggest that AQP4 attenuates Aβ pathogenesis despite its potentially inflammatory side-effects, thus serving as a promising target for treating AD.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 158 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Unknown 157 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 33 21%
Student > Master 25 16%
Student > Bachelor 24 15%
Researcher 22 14%
Student > Doctoral Student 13 8%
Other 25 16%
Unknown 16 10%
Readers by discipline Count As %
Neuroscience 55 35%
Medicine and Dentistry 28 18%
Agricultural and Biological Sciences 23 15%
Biochemistry, Genetics and Molecular Biology 11 7%
Pharmacology, Toxicology and Pharmaceutical Science 4 3%
Other 11 7%
Unknown 26 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2016.
All research outputs
#904,487
of 8,276,988 outputs
Outputs from Molecular Neurodegeneration
#132
of 406 outputs
Outputs of similar age
#36,980
of 245,169 outputs
Outputs of similar age from Molecular Neurodegeneration
#14
of 19 outputs
Altmetric has tracked 8,276,988 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 406 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 245,169 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.