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Attention Score in Context
| Title |
Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits
|
|---|---|
| Published in |
Molecular Neurodegeneration, November 2015
|
| DOI | 10.1186/s13024-015-0056-1 |
| Pubmed ID | |
| Authors |
Zhiqiang Xu, Na Xiao, Yali Chen, Huang Huang, Charles Marshall, Junying Gao, Zhiyou Cai, Ting Wu, Gang Hu, Ming Xiao |
| Abstract |
Preventing or reducing amyloid-beta (Aβ) accumulation in the brain is an important therapeutic strategy for Alzheimer's disease (AD). Recent studies showed that the water channel aquaporin-4 (AQP4) mediates soluble Aβ clearance from the brain parenchyma along the paravascular pathway. However the direct evidence for roles of AQP4 in the pathophysiology of AD remains absent. Here, we reported that the deletion of AQP4 exacerbated cognitive deficits of 12-moth old APP/PS1 mice, with increases in Aβ accumulation, cerebral amyloid angiopathy and loss of synaptic protein and brain-derived neurotrophic factor in the hippocampus and cortex. Furthermore, AQP4 deficiency increased atrophy of astrocytes with significant decreases in interleukin-1 beta and nonsignficant decreases in interleukin-6 and tumor necrosis factor-alpha in hippocampal and cerebral samples. These results suggest that AQP4 attenuates Aβ pathogenesis despite its potentially inflammatory side-effects, thus serving as a promising target for treating AD. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 313 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Unknown | 312 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 53 | 17% |
| Student > Master | 51 | 16% |
| Student > Bachelor | 34 | 11% |
| Researcher | 32 | 10% |
| Student > Doctoral Student | 19 | 6% |
| Other | 41 | 13% |
| Unknown | 83 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 109 | 35% |
| Medicine and Dentistry | 35 | 11% |
| Biochemistry, Genetics and Molecular Biology | 26 | 8% |
| Agricultural and Biological Sciences | 23 | 7% |
| Engineering | 6 | 2% |
| Other | 18 | 6% |
| Unknown | 96 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2023.
All research outputs
#1,693,616
of 23,539,593 outputs
Outputs from Molecular Neurodegeneration
#151
of 872 outputs
Outputs of similar age
#26,184
of 286,648 outputs
Outputs of similar age from Molecular Neurodegeneration
#5
of 18 outputs
Altmetric has tracked 23,539,593 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 872 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.9. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,648 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.