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Stromal Immunology

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Attention for Chapter 3: Fibroblasts and Osteoblasts in Inflammation and Bone Damage
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Chapter title
Fibroblasts and Osteoblasts in Inflammation and Bone Damage
Chapter number 3
Book title
Stromal Immunology
Published in
Advances in experimental medicine and biology, August 2018
DOI 10.1007/978-3-319-78127-3_3
Pubmed ID
Book ISBNs
978-3-31-978125-9, 978-3-31-978127-3
Authors

Jason D. Turner, Amy J. Naylor, Christopher Buckley, Andrew Filer, Paul-Peter Tak

Abstract

This review discusses the important role fibroblasts play in the process of inflammation and the evidence that these cells may drive the persistence of inflammation. Fibroblasts are key components of the stroma normally involved in maintenance of extracellular matrix and tissue function; however, the term 'fibroblast' is used to describe a heterogeneous population of cells that vary in phenotype both between and within anatomical sites. Fibroblasts possess Toll-like receptors allowing them to respond to pathogen and damage-related signals by producing proinflammatory mediators such as IL-6, PGE2, and GM-CSF and can produce a range of chemokines such as CXCL12, CXCL13, and CXCL8 which attract B and T lymphocytes, monocytes, and neutrophils to sites of inflammation. Interactions between leukocytes and fibroblasts can facilitate increased survival of the leukocytes and modulate phenotypes leading to differential gene expression in the presence of mediators involved in inflammation. Fibroblasts also contribute to collateral tissue damage during inflammation through the production of members of the metalloproteinase family and cathepsins and also through induction of osteoclastogenesis leading to increased bone resorption rates. In persistent diseases, fibroblasts obtain an imprinted, aggressive phenotype leading to the production of higher basal levels of proinflammatory cytokines and the ability to damage tissue in the absence of continual stimuli. This aggressive phenotype offers an attractive new target for therapeutics that could help alleviate the burden of persistent inflammation.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 25%
Student > Ph. D. Student 3 25%
Student > Bachelor 1 8%
Student > Doctoral Student 1 8%
Student > Master 1 8%
Other 1 8%
Unknown 2 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 25%
Medicine and Dentistry 2 17%
Immunology and Microbiology 2 17%
Chemistry 1 8%
Materials Science 1 8%
Other 0 0%
Unknown 3 25%