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Stromal Immunology

Overview of attention for book
Attention for Chapter 6: Stromal Cells in the Tumor Microenvironment
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Mentioned by

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1 tweeter

Citations

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1 Dimensions

Readers on

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48 Mendeley
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Chapter title
Stromal Cells in the Tumor Microenvironment
Chapter number 6
Book title
Stromal Immunology
Published in
Advances in experimental medicine and biology, August 2018
DOI 10.1007/978-3-319-78127-3_6
Pubmed ID
Book ISBNs
978-3-31-978125-9, 978-3-31-978127-3
Authors

Alice E. Denton, Edward W. Roberts, Douglas T. Fearon, Denton, Alice E., Roberts, Edward W., Fearon, Douglas T.

Abstract

The tumor microenvironment comprises a mass of heterogeneous cell types, including immune cells, endothelial cells, and fibroblasts, alongside cancer cells. It is increasingly becoming clear that the development of this support niche is critical to the continued uncontrolled growth of the cancer. The tumor microenvironment contributes to the maintenance of cancer stemness and also directly promotes angiogenesis, invasion, metastasis, and chronic inflammation. In this chapter, we describe on the role of fibroblasts, specifically termed cancer-associated fibroblasts (CAFs), in the promotion and maintenance of cancers. CAFs have a multitude of effects on the growth and maintenance of cancer, and here we focus on their roles in modulating immune cells and responses; CAFs both inhibit immune cell access to the tumor microenvironment and inhibit their functions within the tumor. Finally, we describe the potential modulation of CAF function as an adjunct to bolster the effectiveness of cancer immunotherapies.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 23%
Student > Master 10 21%
Student > Bachelor 7 15%
Student > Doctoral Student 4 8%
Other 3 6%
Other 5 10%
Unknown 8 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 23%
Immunology and Microbiology 9 19%
Medicine and Dentistry 6 13%
Agricultural and Biological Sciences 5 10%
Engineering 3 6%
Other 3 6%
Unknown 11 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2018.
All research outputs
#10,701,157
of 13,451,706 outputs
Outputs from Advances in experimental medicine and biology
#1,885
of 3,253 outputs
Outputs of similar age
#199,150
of 266,104 outputs
Outputs of similar age from Advances in experimental medicine and biology
#2
of 3 outputs
Altmetric has tracked 13,451,706 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,253 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,104 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.