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Control of occlusion of middle cerebral artery in perinatal and neonatal mice with magnetic force

Overview of attention for article published in Molecular Brain, August 2018
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Title
Control of occlusion of middle cerebral artery in perinatal and neonatal mice with magnetic force
Published in
Molecular Brain, August 2018
DOI 10.1186/s13041-018-0389-0
Pubmed ID
Authors

Jie-Min Jia, Chuanqi Peng, Yihui Wang, Jie Zheng, Woo-Ping Ge

Abstract

Ischemic perinatal stroke (IPS) is common, resulting in significant mortality and morbidity. In such cases, the incidence of unilateral arterial cerebral infarction is often occluded in the middle cerebral artery (MCA), leading to focal ischemia. In adult rodents, blockage of MCA is the most frequently used strategy for ischemic stroke study. However, modeling MCA occlusion (MCAo) in postnatal day 0-7 (P0-7) mouse pups for IPS study has not been accomplished. Here we occluded the dMCA by inducing the accumulation of magnetic particles (MPs) administered through the superficial temporal vein of mice between P0 and P7, which we called neonatal or perinatal SIMPLE (Stroke Induced with Magnetic Particles). SIMPLE produced either permanent or transient occlusion in the dMCA of perinatal and neonatal mice. Permanent MCA occlusion with SIMPLE resulted in cerebral infarction and neuronal death in the brain. SIMPLE can also be used to reliably produce focal ischemic stroke in neonatal or perinatal mouse brains. As a result, SIMPLE allows the modeling of IPS or focal ischemic stroke for further mechanistic studies in mice, with particular utility for mimicking transient focal ischemia in human pre-term babies, which for the first time here has been accomplished in mice.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 25%
Student > Bachelor 3 19%
Researcher 3 19%
Student > Master 3 19%
Student > Postgraduate 2 13%
Other 1 6%
Readers by discipline Count As %
Neuroscience 7 44%
Medicine and Dentistry 7 44%
Chemistry 1 6%
Unknown 1 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2018.
All research outputs
#10,369,042
of 13,589,098 outputs
Outputs from Molecular Brain
#410
of 623 outputs
Outputs of similar age
#183,730
of 264,930 outputs
Outputs of similar age from Molecular Brain
#1
of 1 outputs
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