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Argonaute 2 and nasopharyngeal carcinoma: a genetic association study and functional analysis

Overview of attention for article published in BMC Cancer, November 2015
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Title
Argonaute 2 and nasopharyngeal carcinoma: a genetic association study and functional analysis
Published in
BMC Cancer, November 2015
DOI 10.1186/s12885-015-1895-4
Pubmed ID
Authors

Peiyao Li, Jinfeng Meng, Yun Zhai, Hongxing Zhang, Lixia Yu, Zhifu Wang, Xiaoai Zhang, Pengbo Cao, Xi Chen, Yuqing Han, Yang Zhang, Huipeng Chen, Yan Ling, Yuxia Li, Ying Cui, Jin-Xin Bei, Yi-Xin Zeng, Fuchu He, Gangqiao Zhou

Abstract

Argonaute 2 (AGO2), a central component of RNA-induced silencing complex, plays critical roles in cancer. We examined whether the single nucleotide polymorphisms (SNPs) of AGO2 were related to the risk of nasopharyngeal carcinoma (NPC). Twenty-five tag SNPs within AGO2 were genotyped in Guangxi population consisting of 855 NPC patients and 1036 controls. The SNPs significantly associated with NPC were further replicated in Guangdong population consisting of 996 NPC patients and 972 controls. Functional experiments were conducted to examine the biologic roles of AGO2 in NPC. A significantly increased risk of advanced lymph node metastasis of NPC was identified for the AGO2 rs3928672 GA + AA genotype compared with GG genotype in both the Guangxi and Guangdong populations (combined odd ratio = 2.08, 95 % confidence interval = 1.44-3.01, P = 8.60 × 10(-5)). Moreover, the AGO2 protein expression levels of rs3928672 GA + AA genotype carriers were higher than the GG genotype carriers in the NPC tissues (P = 0.041), and AGO2 was significantly over-expressed in NPC tissues compared with non-cancerous nasopharyngeal tissues (P = 0.011). In addition, AGO2 knockdown reduced cell proliferation, induced apoptosis, and inhibited migration of NPC cells. Furthermore, gene expression microarray showed that genes altered following AGO2 knockdown were clustered in tumorigenesis and metastasis relevant pathways. Our findings suggest that the genetic polymorphism in AGO2 may be a risk factor for the advanced lymph node metastasis of NPC in Chinese populations, and AGO2 acts as an oncogene in the development of NPC.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 42%
Student > Ph. D. Student 1 8%
Professor 1 8%
Student > Doctoral Student 1 8%
Researcher 1 8%
Other 0 0%
Unknown 3 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 25%
Biochemistry, Genetics and Molecular Biology 2 17%
Medicine and Dentistry 2 17%
Sports and Recreations 1 8%
Social Sciences 1 8%
Other 1 8%
Unknown 2 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2015.
All research outputs
#4,833,367
of 6,535,238 outputs
Outputs from BMC Cancer
#1,970
of 3,089 outputs
Outputs of similar age
#144,161
of 210,012 outputs
Outputs of similar age from BMC Cancer
#145
of 251 outputs
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