Title |
Autoimmune enteropathy with a CD8+ CD7-T-cell small bowel intraepithelial lymphocytosis: case report and literature review
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Published in |
BMC Gastroenterology, November 2011
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DOI | 10.1186/1471-230x-11-131 |
Pubmed ID | |
Authors |
Shrinivas Bishu, Violeta Arsenescu, Eun Y Lee, H David Vargas, Willem JS de Villiers, Razvan Arsenescu |
Abstract |
Adult onset autoimmune enteropathy (AIE) is a rare condition characterized by diarrhea refractory to dietary therapy diagnosed in patients with evidence of autoimmune conditions. Auto-antibodies to gut epithelial cells and other tissues are commonly demonstrated. Despite increasing awareness, the pathogenesis, histologic, immunologic and clinical features of AIE remain uncertain. There remains controversy regarding the diagnostic criteria, the frequency and types of auto-antibodies and associated autoimmune conditions, and the extent and types of histologic and immunologic abnormalities. CD4+ T-cells are thought to at least responsible for this condition; whether other cell types, including B- and other T-cell subsets are involved, are uncertain. We present a unique case of AIE associated with a CD8+CD7- lymphocytosis and review the literature to characterize the histologic and immunologic abnormalities, and the autoantibodies and autoimmune conditions associated with AIE. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 3% |
United States | 1 | 3% |
Germany | 1 | 3% |
Unknown | 28 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 6 | 19% |
Researcher | 5 | 16% |
Student > Bachelor | 4 | 13% |
Student > Doctoral Student | 3 | 10% |
Student > Master | 3 | 10% |
Other | 8 | 26% |
Unknown | 2 | 6% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 21 | 68% |
Agricultural and Biological Sciences | 4 | 13% |
Immunology and Microbiology | 1 | 3% |
Neuroscience | 1 | 3% |
Chemistry | 1 | 3% |
Other | 0 | 0% |
Unknown | 3 | 10% |