Title |
Overlooked Holmes’ clinical signs: reevaluation by recent physiological findings
|
---|---|
Published in |
Cerebellum & Ataxias, November 2015
|
DOI | 10.1186/s40673-015-0033-z |
Pubmed ID | |
Authors |
Takahiro Ishikawa, Shinji Kakei, Hiroshi Mitoma |
Abstract |
Holmes proposed not only the term ataxia, but also opposite clinical signs related to muscle recruitment, which have escaped clinical attention; (1) asthenia, representing delay in initiating muscle contraction and slowness in attaining exertion of full power, and (2) adventitiousness, representing adventitious movements. Recent physiological studies have shown that cerebellar outputs are modified by release or facilitation of Purkinje cell-mediated inhibition on dentate neurons. We believe that asthenia and adventitiousness, which correlate with deficits in the control of disinhibition and inhibition, respectively, deserve more attention in clinical examination. |
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