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A joint Bayesian approach for the analysis of response measured at a primary endpoint and longitudinal measurements

Overview of attention for article published in Statistical Methods in Medical Research, November 2015
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Title
A joint Bayesian approach for the analysis of response measured at a primary endpoint and longitudinal measurements
Published in
Statistical Methods in Medical Research, November 2015
DOI 10.1177/0962280215615003
Pubmed ID
Authors

Zeynep Kalaylioglu, Haydar Demirhan

Abstract

Joint mixed modeling is an attractive approach for the analysis of a scalar response measured at a primary endpoint and longitudinal measurements on a covariate. In the standard Bayesian analysis of these models, measurement error variance and the variance/covariance of random effects are a priori modeled independently. The key point is that these variances cannot be assumed independent given the total variation in a response. This article presents a joint Bayesian analysis in which these variance terms are a priori modeled jointly. Simulations illustrate that analysis with multivariate variance prior in general lead to reduced bias (smaller relative bias) and improved efficiency (smaller interquartile range) in the posterior inference compared with the analysis with independent variance priors.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 27%
Student > Master 3 27%
Lecturer 2 18%
Professor 1 9%
Researcher 1 9%
Other 0 0%
Unknown 1 9%
Readers by discipline Count As %
Mathematics 4 36%
Medicine and Dentistry 3 27%
Environmental Science 1 9%
Unknown 3 27%