Title |
The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases
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Published in |
Molecular and Cellular Pediatrics, February 2015
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DOI | 10.1186/s40348-015-0014-6 |
Pubmed ID | |
Authors |
Ines Mack, Andreas Hector, Marlene Ballbach, Julius Kohlhäufl, Katharina J Fuchs, Alexander Weber, Marcus A Mall, Dominik Hartl |
Abstract |
Chitin, after cellulose, the second most abundant biopolymer on earth, is a key component of insects, fungi, and house-dust mites. Lower life forms are endowed with chitinases to defend themselves against chitin-bearing pathogens. Unexpectedly, humans were also found to express chitinases as well as chitinase-like proteins that modulate immune responses. Particularly, increased levels of the chitinase-like protein YKL-40 have been associated with severe asthma, cystic fibrosis, and other inflammatory disease conditions. Here, we summarize and discuss the potential role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 5% |
Austria | 1 | 5% |
Iceland | 1 | 5% |
Barbados | 1 | 5% |
Unknown | 17 | 81% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 21 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Sweden | 1 | 1% |
Unknown | 95 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 20 | 21% |
Researcher | 14 | 15% |
Student > Doctoral Student | 8 | 8% |
Student > Bachelor | 8 | 8% |
Student > Master | 7 | 7% |
Other | 19 | 20% |
Unknown | 20 | 21% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 21 | 22% |
Biochemistry, Genetics and Molecular Biology | 20 | 21% |
Medicine and Dentistry | 13 | 14% |
Immunology and Microbiology | 10 | 10% |
Engineering | 4 | 4% |
Other | 5 | 5% |
Unknown | 23 | 24% |