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A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

Overview of attention for article published in Nature Medicine, November 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#5 of 7,242)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Citations

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Title
A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence
Published in
Nature Medicine, November 2015
DOI 10.1038/nm.3985
Pubmed ID
Authors

Vineet D Menachery, Boyd L Yount, Kari Debbink, Sudhakar Agnihothram, Lisa E Gralinski, Jessica A Plante, Rachel L Graham, Trevor Scobey, Xing-Yi Ge, Eric F Donaldson, Scott H Randell, Antonio Lanzavecchia, Wayne A Marasco, Zhengli-Li Shi, Ralph S Baric

Abstract

The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome (MERS)-CoV underscores the threat of cross-species transmission events leading to outbreaks in humans. Here we examine the disease potential of a SARS-like virus, SHC014-CoV, which is currently circulating in Chinese horseshoe bat populations. Using the SARS-CoV reverse genetics system, we generated and characterized a chimeric virus expressing the spike of bat coronavirus SHC014 in a mouse-adapted SARS-CoV backbone. The results indicate that group 2b viruses encoding the SHC014 spike in a wild-type backbone can efficiently use multiple orthologs of the SARS receptor human angiotensin converting enzyme II (ACE2), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV. Additionally, in vivo experiments demonstrate replication of the chimeric virus in mouse lung with notable pathogenesis. Evaluation of available SARS-based immune-therapeutic and prophylactic modalities revealed poor efficacy; both monoclonal antibody and vaccine approaches failed to neutralize and protect from infection with CoVs using the novel spike protein. On the basis of these findings, we synthetically re-derived an infectious full-length SHC014 recombinant virus and demonstrate robust viral replication both in vitro and in vivo. Our work suggests a potential risk of SARS-CoV re-emergence from viruses currently circulating in bat populations.

Twitter Demographics

The data shown below were collected from the profiles of 18,342 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 1,179 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
India 1 <1%
Ecuador 1 <1%
United Kingdom 1 <1%
France 1 <1%
Unknown 1173 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 240 20%
Student > Ph. D. Student 189 16%
Student > Master 121 10%
Student > Bachelor 106 9%
Other 78 7%
Other 259 22%
Unknown 186 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 190 16%
Medicine and Dentistry 158 13%
Agricultural and Biological Sciences 143 12%
Immunology and Microbiology 74 6%
Engineering 53 4%
Other 296 25%
Unknown 265 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 13719. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 October 2020.
All research outputs
#28
of 16,075,831 outputs
Outputs from Nature Medicine
#5
of 7,242 outputs
Outputs of similar age
#1
of 287,426 outputs
Outputs of similar age from Nature Medicine
#1
of 81 outputs
Altmetric has tracked 16,075,831 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,242 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 60.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,426 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.