Title |
Proteomic analysis of saliva: a unique tool to distinguish primary Sjögren's syndrome from secondary Sjögren's syndrome and other sicca syndromes
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Published in |
Arthritis Research & Therapy, November 2011
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DOI | 10.1186/ar3523 |
Pubmed ID | |
Authors |
Chiara Baldini, Laura Giusti, Federica Ciregia, Ylenia Da Valle, Camillo Giacomelli, Elena Donadio, Francesca Sernissi, Laura Bazzichi, Gino Giannaccini, Stefano Bombardieri, Antonio Lucacchini |
Abstract |
A growing interest has arisen in salivary proteomics as a tool for the identification of biomarkers for primary Sjögren's syndrome (pSS). Nonetheless, only a limited number of preclinical validation studies have been performed, limiting the possibility of translating proteomic results into clinical practice. The primary aim of this study was to refine the diagnostic power of a panel of candidate salivary biomarkers described in pSS with respect to both healthy volunteers and pathological controls. We also explored the pathogenetic function of the detected putative biomarkers both in the local exocrinopathy and in the systemic inflammatory processes of SS. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 2 | 2% |
Netherlands | 1 | <1% |
Colombia | 1 | <1% |
China | 1 | <1% |
United States | 1 | <1% |
Unknown | 112 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 22 | 19% |
Student > Ph. D. Student | 13 | 11% |
Student > Master | 13 | 11% |
Student > Bachelor | 11 | 9% |
Other | 8 | 7% |
Other | 25 | 21% |
Unknown | 26 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 40 | 34% |
Agricultural and Biological Sciences | 17 | 14% |
Biochemistry, Genetics and Molecular Biology | 10 | 8% |
Immunology and Microbiology | 8 | 7% |
Nursing and Health Professions | 3 | 3% |
Other | 11 | 9% |
Unknown | 29 | 25% |