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DNA methylation subgroups in melanoma are associated with proliferative and immunological processes

Overview of attention for article published in BMC Medical Genomics, January 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Mentioned by

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3 tweeters
facebook
2 Facebook pages

Citations

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18 Dimensions

Readers on

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28 Mendeley
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Title
DNA methylation subgroups in melanoma are associated with proliferative and immunological processes
Published in
BMC Medical Genomics, January 2015
DOI 10.1186/s12920-015-0147-4
Pubmed ID
Authors

Martin Lauss, Markus Ringnér, Anna Karlsson, Katja Harbst, Christian Busch, Jürgen Geisler, Per E Lønning, Johan Staaf, Göran Jönsson

Abstract

DNA methylation at CpG dinucleotides is modified in tumorigenesis with potential impact on transcriptional activity. We used the Illumina 450 K platform to evaluate DNA methylation patterns of 50 metastatic melanoma tumors, with matched gene expression data. We identified three different methylation groups and validated the groups in independent data from The Cancer Genome Atlas. One group displayed hypermethylation of a developmental promoter set, genome-wide demethylation, increased proliferation and activity of the SWI/SNF complex. A second group had a methylation pattern resembling stromal and leukocyte cells, over-expressed an immune signature and had improved survival rates in metastatic tumors (p < 0.05). A third group had intermediate methylation levels and expressed both proliferative and immune signatures. The methylation groups corresponded to some degree with previously identified gene expression phenotypes. Melanoma consists of divergent methylation groups that are distinguished by promoter methylation, proliferation and content of immunological cells.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 2 7%
Norway 1 4%
Unknown 25 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 29%
Student > Ph. D. Student 5 18%
Student > Doctoral Student 3 11%
Student > Master 2 7%
Other 2 7%
Other 4 14%
Unknown 4 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 29%
Biochemistry, Genetics and Molecular Biology 8 29%
Medicine and Dentistry 5 18%
Computer Science 1 4%
Immunology and Microbiology 1 4%
Other 1 4%
Unknown 4 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2015.
All research outputs
#2,353,023
of 6,566,187 outputs
Outputs from BMC Medical Genomics
#155
of 387 outputs
Outputs of similar age
#77,355
of 209,505 outputs
Outputs of similar age from BMC Medical Genomics
#11
of 29 outputs
Altmetric has tracked 6,566,187 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 387 research outputs from this source. They receive a mean Attention Score of 4.4. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,505 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.