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Unleashing endogenous TNF-alpha as a cancer immunotherapeutic

Overview of attention for article published in Journal of Translational Medicine, August 2018
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

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6 news outlets
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25 X users
patent
2 patents

Citations

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176 Dimensions

Readers on

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333 Mendeley
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Title
Unleashing endogenous TNF-alpha as a cancer immunotherapeutic
Published in
Journal of Translational Medicine, August 2018
DOI 10.1186/s12967-018-1611-7
Pubmed ID
Authors

Steven F. Josephs, Thomas E. Ichim, Stephen M. Prince, Santosh Kesari, Francesco M. Marincola, Anton Rolando Escobedo, Amir Jafri

Abstract

Tumor necrosis factor (TNF)-alpha was originally identified in the 1970s as the serum mediator of innate immunity capable of inducing hemorrhagic necrosis in tumors. Today, a wide spectrum of biological activities have been attributed to this molecule, and clinical translation has mainly occurred not in using it to treat cancer, but rather to inhibit its effects to treat autoimmunity. Clinical trials utilizing systemic TNF-alpha administration have resulted in an unacceptable level of toxicities, which blocked its development. In contrast, localized administration of TNF-alpha in the form of isolated limb perfusion have yielded excellent results in soft tissue sarcomas. Here we describe a novel approach to leveraging the potent antineoplastic activities of TNF-alpha by enhancing activity of locally produced TNF-alpha through extracorporeal removal of soluble TNF-alpha receptors. Specifically, it is known that cancerous tissues are infiltrated with monocytes, T cells, and other cells capable of producing TNF-alpha. It is also known that tumors, as well as cells in the tumor microenvironment produce soluble TNF-alpha receptors. The authors believe that by selectively removing soluble TNF-alpha receptors local enhancement of endogenous TNF-alpha activity may provide for enhanced tumor cell death without associated systemic toxicities.

X Demographics

X Demographics

The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 333 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 333 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 48 14%
Student > Ph. D. Student 47 14%
Student > Master 38 11%
Researcher 33 10%
Other 15 5%
Other 29 9%
Unknown 123 37%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 66 20%
Medicine and Dentistry 40 12%
Immunology and Microbiology 27 8%
Pharmacology, Toxicology and Pharmaceutical Science 21 6%
Agricultural and Biological Sciences 17 5%
Other 28 8%
Unknown 134 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 64. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2024.
All research outputs
#671,728
of 25,483,400 outputs
Outputs from Journal of Translational Medicine
#141
of 4,658 outputs
Outputs of similar age
#14,372
of 345,811 outputs
Outputs of similar age from Journal of Translational Medicine
#2
of 86 outputs
Altmetric has tracked 25,483,400 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,658 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,811 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.